Does selenium modify neurobehavioural impacts of developmental methylmercury exposure in mice?

There is controversy as to whether low-level chronic exposure to methylmercury (MeHg) through maternal fish consumption may cause subtle effects in the developing child, owing in part to the potential ameliorating effects of beneficial seafood nutrients. The aim of the present investigation was to assess the ameliorating potential of selenium (Se: as the naturally occurring methionine complex) on the neurobehavioural toxicity of foodborne MeHg (as the naturally occurring cysteinate) in prenatally exposed mice. Pups from clams exposed to a diet containing 3 mg/kg of MeHg fed throughout gestation showed delayed fur development and impaired performance in a motor function assessment. These effects were not apparent in pups born to darns concurrently exposed to Se (at 1.3 mg/kg). These results. using natural dietary forms of the elements administered through the relevant exposure pathway, suggest only minor impacts of MeHgCys on neurobehaviour, and possible amelioration of these effects by Se. (C) 2009 Elsevier B.V. All rights reserved.