What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs

被引：207
作者：
Alvim, Haline G. O. [1 ]
da Silva Junior, Eufranio N. [2 ]
Neto, Brenno A. D. [1 ]
机构：
[1] Univ Brasilia IQ UnB, Lab Med & Technol Chem, BR-70904970 Brasilia, DF, Brazil
[2] Univ Fed Minas Gerais, Dept Chem, Inst Exact Sci, Lab Synthet & Heterocycl Chem, BR-31270901 Belo Horizonte, MG, Brazil
来源：
RSC ADVANCES | 2014年 / 4卷 / 97期
关键词：
CHARGE-TAGGED REAGENTS; MASS-SPECTROMETRY; ORGANIC-SYNTHESIS; CATALYSIS; CHEMISTRY; ESI-MS(/MS);
D O I：
10.1039/c4ra10651b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The current manuscript describes the importance, mechanism propositions, evidence and controversies associated with multicomponent reactions (MCRs). The following multicomponent reactions are presented and critically evaluated: the Biginelli, Hantzsch, Mannich, Passerini and Ugi reactions. The aim of this review is to highlight what we already know about the mechanisms associated with these MCRs and the evidence supporting the proposed reaction pathways. Controversies and prospects are also discussed herein.
引用
收藏
页码：54282 / 54299
页数：18
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