Relationship Between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women With Osteoporosis

被引：53

作者：

Krege, John H. ^{[1
]}

Kendler, David ^{[2
]}

Krohn, Kelly ^{[1
]}

Genant, Harry ^{[3
]}

Alam, Jahangir ^{[1
]}

Berclaz, Pierre-Yves ^{[1
]}

Coffey, Barbara ^{[1
]}

Loghin, Corina ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA

[2] Univ British Columbia, Vancouver, ON, Canada

[3] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

JOURNAL OF CLINICAL DENSITOMETRY | 2015年 / 18卷 / 04期

关键词：

Height loss; lung volume; osteoporosis; pulmonary function; vertebral fractures; PREVALENCE; MORTALITY; RISK; DISEASE; COPD;

D O I：

10.1016/j.jocd.2015.02.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this analysis was to assess the association of osteoporosis-related vertebral fracture burden and pulmonary function. This study also examined the relationship between vertebral fracture burden and height loss, estimated by arm span - height. This was a single-site and single-visit study. Patients had a history of at least 1 moderate or severe vertebral fracture. Vertebral fracture burden was quantified using the spinal deformity index (SDI). Pulmonary function during inspiration was determined by spirometry. Forty-one women aged 70-91 completed the study. Vertebral fracture burden negatively correlated with forced inspiratory vital capacity and inspiratory time. For each unit increase in SDI, forced inspiratory vital capacity decreased by 1.62%, and inspiratory time decreased by 2.39%. There was no correlation between SDI and measures of inspiratory flow. For each unit increase in SDI, height decreased by about 0.5 cm. Vertebral fractures were associated with decreased lung volume and height loss.

引用

页码：506 / 511

页数：6

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