Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines

被引：104

作者：

Rashad, Aymn E. ^{[1
]}

Hegab, Mohamed I. ^{[1
]}

Abdel-Megeid, Randal E. ^{[1
]}

Fathalla, Nahed ^{[2
]}

Abdel-Megeid, Farouk M. E. ^{[1
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo, Egypt

[2] Al Azhar Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 08期

关键词：

Synthesis; Pyrazoles; Pyrazolopyrimidines; C-nucleosides; Antiviral evaluation; BIOLOGICAL EVALUATION; ANTIVIRAL EVALUATION; C-NUCLEOSIDES; DERIVATIVES;

D O I：

10.1016/j.ejmech.2009.02.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2-10. Furthermore, the preparation of sugar hydrazone derivatives 11a,b, 12a,b and their annelated C-nucleosides 13a,b was described. Some of the prepared products revealed promising antiviral activity against herpes simplex virus type-1 (HSV-1) in comparison to Acyclovir as a control. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3285 / 3292

页数：8

共 24 条

[1] Synthesis and antiviral evaluation of some sugar arylglycinoylhydrazones and their oxadiazoline derivatives [J].