Effect of Statin Therapy on Mortality and Recurrence of Intracerebral Hemorrhage in Patients With Spontaneous Intracerebral Hemorrhage

被引:2
作者
Jamil, Sidra [1 ]
Batool, Saima [2 ]
Shaik, Tanveer Ahamad [3 ]
Shakil, Urooba [4 ]
Zahra, Tafseer [1 ]
Zahoor, Mohammad Munim [5 ]
Chunchu, Venkata Anirudh [6 ]
Ali, Neelum [4 ]
机构
[1] Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CT USA
[2] Hameed Latif Hosp, Internal Med, Lahore, Pakistan
[3] Univ Louisville, Sch Med, Cardiovasc Med, Louisville, KY 40292 USA
[4] Univ Hlth Sci, Internal Med, Lahore, Pakistan
[5] Ghurki Trust Teaching Hosp, Internal Med, Lahore, Pakistan
[6] Avalon Univ, Sch Med, Med, Willemstad, Neth Antilles
关键词
meta; -analysis; cholestrol; statin therapy; mortality; intracranial hemorrhage; STROKE; PREVENTION; RISK;
D O I
10.7759/cureus.31150
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Statins can play an essential role in the tertiary and primary prevention of cardiovascular events by reduction of cholesterol in a stroke patient. This meta-analysis aims to assess statin therapy's effect on mortality and recurrence of Intracranial Hemorrhage (ICH) in patients with spontaneous ICH. The current meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta -analyses (PRISMA) guidelines. A systematic search was performed using PubMed, EMBASE, and Cochrane Library to identify studies assessing the use of statins in patients with ICH. The primary outcome assessed in the current meta-analysis was a hemorrhagic stroke. The secondary outcomes included cardiac-related events and all-cause mortality. A total of 9 studies were included in the current meta-analysis enrolling 49027 patients, with 8094 patients on statin therapy and 40933 patients in the control group. The risk of recurrent ICH was significantly lower in patients receiving stains (RR: 0.81, 95% CI: 0.67-0.99, p-value: 0.02) compared to placebo. However, no significant differences were observed regarding all-cause mortality (RR: 0.80, 95% CI: 0.53-1.20, p-value: 0.27) and cardiovascular events (RR: 1.24, 95% CI: 0.88-1.74). In ICH patients, statins can reduce the risk of recurrent ICH in patients with a history of ICH. However, statins had no significant effect on all-cause mortality and cardiovascular events.
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页数:7
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