Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection

被引:3
作者
Castaneda-Delgado, Julio E. [1 ,2 ]
Cervantes-Villagrana, Alberto [1 ,3 ]
Serrano-Escobedo, Carmen J. [1 ]
Frausto-Lujan, Isabel [1 ]
Rivas-Santiago, Cesar [4 ]
Enciso-Moreno, Jose A. [1 ]
Rivas-Santiago, Bruno [1 ]
机构
[1] Mexican Inst Social Secur, Med Res Unit Zacatecas, Zacatecas, Mexico
[2] Autonomous Univ San Luis Potosi, Fac Med, Dept Immunol, San Luis Potosi, Mexico
[3] Autonomous Univ Zacatecas, Acad Unit Chem Sci, Zacatecas, Mexico
[4] Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Environm & Occupat Hlth, Ctr Global Publ Hlth, Piscataway, NJ 08854 USA
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2014年 / 109卷 / 03期
关键词
tuberculosis; latent infection; antimicrobial peptides; tuberculin skin test; QuantiFERON; biomarker; CATHELICIDIN LL-37; NEUTROPHILS; DEFENSINS;
D O I
10.1590/0074-0276140348
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
It has been reported that patients with progressive tuberculosis (TB) express abundant amounts of the antimicrobial peptides (AMPs) cathelicidin (LL-37) and human neutrophil peptide-1 (HNP-1) in circulating cells, whereas latent TB infected donors showed no differences when compared with purified protein derivative (PPD) and QuantiFERON (R)-TB Gold (QFT)-healthy individuals. The aim of this study was to determine whether LL-37 and HNP-1 production correlates with higher tuberculin skin test (TST) and QFT values in TB household contacts. Twenty-six TB household contact individuals between 26-58 years old TST and QFT positive with at last two years of latent TB infection were recruited. AMPs production by polymorphonuclear cells was determined by flow cytometry and correlation between TST and QFT values was analysed. Our results showed that there is a positive correlation between levels of HNP-1 and LL-37 production with reactivity to TST and/or QFT levels. This preliminary study suggests the potential use of the expression levels of these peptides as biomarkers for progression in latent infected individuals.
引用
收藏
页码:330 / 334
页数:5
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