Twist: a new link from hypoxia to fibrosis

被引：16

作者：

Bechtel, Wibke ^{[1
]}

Zeisberg, Michael ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Matrix Biol, Boston, MA 02215 USA

来源：

KIDNEY INTERNATIONAL | 2009年 / 75卷 / 12期

关键词：

MESENCHYMAL TRANSITION; MORPHOGENESIS;

D O I：

10.1038/ki.2009.102

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Sun et al. demonstrate that hypoxia causes epithelial-to-mesenchymal transition by activating Twist, a transcription factor known to mediate both acquisition of a mesenchymal phenotype and resistance to apoptosis in cancer cells. This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis. Kidney International (2009) 75, 1255-1256. doi:10.1038/ki.2009.102

引用

收藏

页码：1255 / 1256

页数：2

相关论文

共 10 条

[1] Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence [J].

Ansieau, Stephane ;

Bastid, Jeremy ;

Doreau, Agnes ;

Morel, Anne-Pierre ;

Bouchet, Benjamin P. ;

Thomas, Clemence ;

Fauvet, Frederique ;

Puisieux, Isabelle ;

Doglioni, Claudio ;

Piccinin, Sara ;

Maestro, Roberta ;

Voeltzel, Thibault ;

Selmi, Abdelkader ;

Valsesia-Wittmann, Sandrine ;

de Fromentel, Claude Caron ;

Puisieux, Alain .

CANCER CELL, 2008, 14 (01) :79-89

[2] TWIST IS REQUIRED IN HEAD MESENCHYME FOR CRANIAL NEURAL-TUBE MORPHOGENESIS [J].

CHEN, ZF ;

BEHRINGER, RR .

GENES & DEVELOPMENT, 1995, 9 (06) :686-699

[3] Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia [J].

Fine, LG ;

Bandyopadhyay, D ;

Norman, JT .

KIDNEY INTERNATIONAL, 2000, 57 :S22-S26

[4] Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition [J].

Higgins, Debra F. ;

Kimura, Kuniko ;

Bernhardt, Wanja M. ;

Shrimanker, Nikita ;

Akai, Yasuhiro ;

Hohenstein, Bernd ;

Saito, Yoshihiko ;

Johnson, Randall S. ;

Kretzler, Matthias ;

Cohen, Clemens D. ;

Eckardt, Kai-Uwe ;

Iwano, Masayuki ;

Haase, Volker H. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :3810-3820

[5] Epithelial-mesenchymal transition and its implications for fibrosis [J].

Kalluri, R ;

Neilson, EG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (12) :1776-1784

[6] twist is a potential oncogene that inhibits apoptosis [J].

Maestro, R ;

Dei Tos, AP ;

Hamamori, Y ;

Krasnokutsky, S ;

Sartorelli, V ;

Kedes, L ;

Doglioni, C ;

Beach, DH ;

Hannon, GJ .

GENES & DEVELOPMENT, 1999, 13 (17) :2207-2217

[7] Transdifferentiation of cultured tubular cells induced by hypoxia [J].

Manotham, K ;

Tanaka, T ;

Matsumoto, M ;

Ohse, T ;

Inagi, R ;

Miyata, T ;

Kurokawa, K ;

Fujita, T ;

Ingelfinger, JR ;

Nangaku, M .

KIDNEY INTERNATIONAL, 2004, 65 (03) :871-880

[8] Overview of factors contributing to the pathophysiology of progressive renal disease [J].

Schlondorff, Detlef O. .

KIDNEY INTERNATIONAL, 2008, 74 (07) :860-866

[9] Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition [J].

Sun, Shiren ;

Ning, Xiaoxuan ;

Zhang, Yanqi ;

Lu, Yuanyuan ;

Nie, Yongzhan ;

Han, Shuang ;

Liu, Lili ;

Du, Rui ;

Xia, Lin ;

He, Lijie ;

Fan, Daiming .

KIDNEY INTERNATIONAL, 2009, 75 (12) :1278-1287

[10] Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis [J].

Yang, J ;

Mani, SA ;

Donaher, JL ;

Ramaswamy, S ;

Itzykson, RA ;

Come, C ;

Savagner, P ;

Gitelman, I ;

Richardson, A ;

Weinberg, RA .

CELL, 2004, 117 (07) :927-939