Integrins as biomechanical sensors of the microenvironment

被引:819
作者
Kechagia, Jenny Z. [1 ]
Ivaska, Johanna [2 ,3 ,4 ]
Roca-Cusachs, Pere [1 ,5 ]
机构
[1] Inst Bioengn Catalonia IBEC, BIST, Barcelona, Spain
[2] Univ Turku, Turku Biosci Ctr, Turku, Finland
[3] Abo Akad Univ, Turku, Finland
[4] Univ Turku, Dept Biochem, Turku, Finland
[5] Univ Barcelona, Barcelona, Spain
基金
芬兰科学院; 欧盟地平线“2020”;
关键词
CANCER-ASSOCIATED FIBROBLASTS; EPITHELIAL-MESENCHYMAL TRANSITION; MOTOR-CLUTCH MODEL; EXTRACELLULAR-MATRIX; CELL-MIGRATION; FORCE TRANSMISSION; FOCAL ADHESIONS; MYOSIN-II; LYSOSOMAL DEGRADATION; MOLECULAR-MECHANISMS;
D O I
10.1038/s41580-019-0134-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional hubs transmitting signals between cells and their environment. Recent evidence has shown that their combined biochemical and mechanical properties also allow integrins to sense, respond to and interact with ECM of differing properties with exquisite specificity. Here, we review this work first by providing an overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering. Then, we address how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals, such as rigidity, composition and spatial distribution. Finally, we discuss the importance of this sensing for major cell functions by taking cell migration and cancer as examples.
引用
收藏
页码:457 / 473
页数:17
相关论文
共 229 条
[1]   Integrin endosomal signalling suppresses anoikis [J].
Alanko, Jonna ;
Mai, Anja ;
Jacquemet, Guillaume ;
Schauer, Kristine ;
Kaukonen, Riina ;
Saari, Markku ;
Goud, Bruno ;
Ivaska, Johanna .
NATURE CELL BIOLOGY, 2015, 17 (11) :1412-1421
[2]   Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].
Albrengues, Jean ;
Shields, Mario A. ;
Ng, David ;
Park, Chun Gwon ;
Ambrico, Alexandra ;
Poindexter, Morgan E. ;
Upadhyay, Priya ;
Uyeminami, Dale L. ;
Pommier, Arnaud ;
Kuttner, Victoria ;
Bruzas, Emilis ;
Maiorino, Laura ;
Bautista, Carmelita ;
Carmona, Ellese M. ;
Gimotty, Phyllis A. ;
Fearon, Douglas T. ;
Chang, Kenneth ;
Lyons, Scott K. ;
Pinkerton, Kent E. ;
Trotman, Lloyd C. ;
Goldberg, Michael S. ;
Yeh, Johannes T. -H. ;
Egeblad, Mikala .
SCIENCE, 2018, 361 (6409) :1353-+
[3]   The significance of integrin ligand nanopatterning on lipid raft clustering in hematopoietic stem cells [J].
Altrock, Eva ;
Muth, Christine A. ;
Klein, Gerd ;
Spatz, Joachim P. ;
Lee-Thedieck, Cornelia .
BIOMATERIALS, 2012, 33 (11) :3107-3118
[4]   Nanoscale Integrin Ligand Patterns Determine Melanoma Cell Behavior [J].
Amschler, Katharina ;
Erpenbeck, Luise ;
Kruss, Sebastian ;
Schoen, Michael P. .
ACS NANO, 2014, 8 (09) :9113-9125
[5]   Activation of integrin function by nanopatterned adhesive interfaces [J].
Arnold, M ;
Cavalcanti-Adam, EA ;
Glass, R ;
Blümmel, J ;
Eck, W ;
Kantlehner, M ;
Kessler, H ;
Spatz, JP .
CHEMPHYSCHEM, 2004, 5 (03) :383-388
[6]   Cancer-associated fibroblasts lead tumor invasion through integrin-β3-dependent fibronectin assembly [J].
Attieh, Youmna ;
Clark, Andrew G. ;
Grass, Carina ;
Richon, Sophie ;
Pocard, Marc ;
Mariani, Pascale ;
Elkhatib, Nadia ;
Betz, Timo ;
Gurchenkov, Basile ;
Vignjevic, Danijela Matic .
JOURNAL OF CELL BIOLOGY, 2017, 216 (11) :3509-3520
[7]   Extracellular rigidity sensing by talin isoform-specific mechanical linkages [J].
Austen, Katharina ;
Ringer, Pia ;
Mehlich, Alexander ;
Chrostek-Grashoff, Anna ;
Kluger, Carleen ;
Klingner, Christoph ;
Sabass, Benedikt ;
Zent, Roy ;
Rief, Matthias ;
Grashoff, Carsten .
NATURE CELL BIOLOGY, 2015, 17 (12) :1597-1606
[8]   The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions [J].
Balcioglu, Hayri E. ;
van Hoorn, Hedde ;
Donato, Dominique M. ;
Schmidt, Thomas ;
Danen, Erik H. J. .
JOURNAL OF CELL SCIENCE, 2015, 128 (07) :1316-1326
[9]   Shifting the optimal stiffness for cell migration [J].
Bangasser, Benjamin L. ;
Shamsan, Ghaidan A. ;
Chan, Clarence E. ;
Opoku, Kwaku N. ;
Tuzel, Erkan ;
Schlichtmann, Benjamin W. ;
Kasim, Jesse A. ;
Fuller, Benjamin J. ;
McCullough, Brannon R. ;
Rosenfeld, Steven S. ;
Odde, David J. .
NATURE COMMUNICATIONS, 2017, 8
[10]   Master Equation-Based Analysis of a Motor-Clutch Model for Cell Traction Force [J].
Bangasser, Benjamin L. ;
Odde, David J. .
CELLULAR AND MOLECULAR BIOENGINEERING, 2013, 6 (04) :449-459