Intestinal Microbiota: Facts and Fiction

被引：30

作者：

Kverka, Miloslav ^{[1
,2
]}

Tlaskalova-Hogenova, Helena ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Microbiol, Prague, Czech Republic

[2] Acad Sci Czech Republ, Inst Expt Med, Prague, Czech Republic

来源：

DIGESTIVE DISEASES | 2017年 / 35卷 / 1-2期

关键词：

Dysbiosis; Gnotobiotic animals; Gut microbiota; Inflammatory bowel diseases; Probiotics; INFLAMMATORY BOWEL DISEASES; MUCOSA-ASSOCIATED BACTERIA; GUT MICROBIOTA; ESCHERICHIA-COLI; GERM-FREE; AUTOIMMUNE-DISEASES; CROHNS-DISEASE; IMPACT; COMMENSAL; PATHOGENESIS;

D O I：

10.1159/000449095

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In humans, the gut microbiota forms a complex ecosystem consisting of a vast number of bacteria, Archaea, fungi and viruses. It represents a major stimulus to the development of the immune system and many other physiological functions, so that it may shape the individual's susceptibility to infectious and immune-mediated diseases. The emergence of new '-omics' methods recently revolutionized the way we study the host-microbe interactions, but they also raised new questions and issues. In this review, we discuss the impact of these new data on the current and future therapies for chronic inflammatory diseases. We also outline the major conceptual, technical and interpretational issues that recently led to some misleading conclusions and discuss in brief the current research directions in the field. (C) 2017 S. Karger AG, Basel

引用

页码：139 / 147

页数：9

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