No Evidence for Passive Gene-Environment Correlation or the Influence of Genetic Risk for Psychiatric Disorders on Adult Body Composition via the Adoption Design

被引：3
作者：
Hunjan, Avina K. [1 ,2 ]
Cheesman, Rosa [1 ]
Coleman, Jonathan R., I [1 ,2 ]
Hubel, Christopher [1 ,2 ,3 ,4 ]
Eley, Thalia C. [1 ,2 ]
Breen, Gerome [1 ,2 ]
机构：
[1] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England
[2] South London & Maudsley NHS Trust, NIHR Maudsley Biomed Res Ctr, London, England
[3] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[4] Aarhus Univ, Natl Ctr Register Based Res, Dept Econ & Business Econ, Aarhus, Denmark
来源：
BEHAVIOR GENETICS | 2021年 / 51卷 / 01期
基金：
英国医学研究理事会;
关键词：
Genomics; Psychiatric disorders; Body composition; Polygenic scores; Heritability; Passive gene-environment correlation; Adoption; MASS INDEX; BIOLOGICAL INSIGHTS; ATYPICAL FEATURES; CHILDHOOD OBESITY; POOLED ANALYSIS; UK BIOBANK; SCHIZOPHRENIA; ASSOCIATION; DEPRESSION; LOCI;
D O I：
10.1007/s10519-020-10028-6
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The relationship between genetic and environmental risk is complex and for many traits, estimates of genetic effects may be inflated by passive gene-environment correlation. This arises because biological offspring inherit both their genotypes and rearing environment from their parents. We tested for passive gene-environment correlation in adult body composition traits using the 'natural experiment' of childhood adoption, which removes passive gene-environment correlation within families. Specifically, we compared 6165 adoptees with propensity score matched non-adoptees in the UK Biobank. We also tested whether passive gene-environment correlation inflates the association between psychiatric genetic risk and body composition. We found no evidence for inflation of heritability or polygenic scores in non-adoptees compared to adoptees for a range of body composition traits. Furthermore, polygenic risk scores for anorexia nervosa, attention-deficit/hyperactivity disorder and schizophrenia did not differ in their influence on body composition traits in adoptees and non-adoptees. These findings suggest that passive gene-environment correlation does not inflate genetic effects for body composition, or the influence of psychiatric disorder genetic risk on body composition. Our design does not look at passive gene-environment correlation in childhood, and does not test for 'pure' environmental effects or the effects of active and evocative gene-environment correlations, where child genetics directly influences home environment. However, these findings suggest that genetic influences identified for body composition in this adult sample are direct, and not confounded by the family environment provided by biological relatives.
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页码：58 / 67
页数：10
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