The Inflammasomes in Autoinflammatory Diseases with Skin Involvement

被引：42

作者：

Beer, Hans-Dietmar ^{[1
]}

Contassot, Emmanuel ^{[1
]}

French, Lars E. ^{[1
]}

机构：

[1] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2014年 / 134卷 / 07期

关键词：

PYOGENIC ARTHRITIS; PYODERMA-GANGRENOSUM; NLRP3; INFLAMMASOME; AIM2; PAPA SYNDROME; MAST-CELLS; ACTIVATION; CANAKINUMAB; IL-1-BETA; SECRETION;

D O I：

10.1038/jid.2014.76

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

During the past years, significant progress in the understanding of the complexity, regulation, and relevance of innate immune responses underlying several inflammatory conditions with neutrophilic skin involvement has been made. These diseases belong to the novel class of autoinflammatory diseases, and several are caused by mutations in genes regulating the function of innate immune complexes, termed inflammasomes, leading to enhanced secretion of the proinflammatory cytokine IL-1 beta. Consequently, targeting of IL-1 beta has proven successful in the treatment of these diseases, and the identification of related pathogenic mechanisms in other more common skin diseases characterized by autoinflammation and neutrophilic tissue damage also provides extended opportunities for therapy by interfering with IL-1 signaling.

引用

页码：1805 / 1810

页数：6

共 50 条

[1] Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α [J].

Afonina, Inna S. ;

Tynan, Graham A. ;

Logue, Susan E. ;

Cullen, Sean P. ;

Bots, Michael ;

Luethi, Alexander U. ;

Reeves, Emer P. ;

McElvaney, Noel G. ;

Medema, Jan P. ;

Lavelle, Ed C. ;

Martin, Seamus J. .

MOLECULAR CELL, 2011, 44 (02) :265-278

[2] NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[3] An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist [J].

Aksentijevich, Ivona ;

Masters, Seth L. ;

Ferguson, Polly J. ;

Dancey, Paul ;

Frenkel, Joost ;

van Royen-Kerkhoff, Annet ;

Laxer, Ron ;

Tedgard, Ulf ;

Cowen, Edward W. ;

Pham, Tuyet-Hang ;

Booty, Matthew ;

Estes, Jacob D. ;

Sandler, Netanya G. ;

Plass, Nicole ;

Stone, Deborah L. ;

Turner, Maria L. ;

Hill, Suvimol ;

Butman, John A. ;

Schneider, Rayfel ;

Babyn, Paul ;

El-Shanti, Hatem I. ;

Pope, Elena ;

Barron, Karyl ;

Bing, Xinyu ;

Laurence, Arian ;

Lee, Chyi-Chia R. ;

Chapelle, Dawn ;

Clarke, Gillian I. ;

Ohson, Kamal ;

Nicholson, Marc ;

Gadina, Massimo ;

Yang, Barbara ;

Korman, Benjamin D. ;

Gregersen, Peter K. ;

van Hagen, P. Martin ;

Hak, A. Elisabeth ;

Huizing, Marjan ;

Rahman, Proton ;

Douek, Daniel C. ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Goldbach-Mansky, Raphaela .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2426-2437

[4] Schnitzler's syndrome with prominent neutrophil infiltration misdiagnosed as Sweet's syndrome: a typical example of urticarial neutrophilic dermatosis [J].

Asahina, A. ;

Sakurai, N. ;

Suzuki, Y. ;

Narushima, K. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2010, 35 (04) :e123-e126

[5] Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[6] Pyroptosis: host cell death and inflammation [J].

Bergsbaken, Tessa ;

Fink, Susan L. ;

Cookson, Brad T. .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (02) :99-109

[7] TLRs and innate immunity [J].

Beutler, Bruce A. .

BLOOD, 2009, 113 (07) :1399-1407

[8] Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra [J].

Brenner, M. ;

Ruzicka, T. ;

Plewig, G. ;

Thomas, P. ;

Herzer, P. .

BRITISH JOURNAL OF DERMATOLOGY, 2009, 161 (05) :1199-1201

[9] Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity [J].

Brydges, Susannah D. ;

Mueller, James L. ;

McGeough, Matthew D. ;

Pena, Carla A. ;

Misaghi, Amirhossein ;

Gandhi, Chhavi ;

Putnam, Chris D. ;

Boyle, David L. ;

Firestein, Gary S. ;

Horner, Anthony A. ;

Soroosh, Pejman ;

Watford, Wendy T. ;

O'Shea, John J. ;

Kastner, Daniel L. ;

Hoffman, Hal M. .

IMMUNITY, 2009, 30 (06) :875-887

[10] New insights into the mechanism of IL-1β maturation [J].

Burns, K ;

Martinon, F ;

Tschopp, J .

CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (01) :26-30

← 1 2 3 4 5 →