Trafficking mechanisms and regulation of TRPC channels

被引：24

作者：

de Souza, Lorena Brito ^{[1
]}

Ambudkar, Indu S. ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Secretory Physiol Sect, Mol Physiol & Therapeut Branch, NIH, Bethesda, MD 20892 USA

来源：

CELL CALCIUM | 2014年 / 56卷 / 02期

关键词：

TRPC channels; Intracellular trafficking; Microdomains; Ca2+ signaling; Regulation; OPERATED CA2+ ENTRY; PLASMA-MEMBRANE LOCALIZATION; SURFACE EXPRESSION; SIGNALING COMPLEX; HUMAN HOMOLOG; RECEPTOR; PROTEIN; ACTIVATION; RELEASE; DOMAIN;

D O I：

10.1016/j.ceca.2014.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TRPC channels are Ca2+-permeable cation channels which are regulated downstream from receptor-coupled PIP2 hydrolysis. These channels contribute to a wide variety of cellular functions. Loss or gain of channel function has been associated with dysfunction and aberrant physiology. TRPC channel functions are influenced by their physical and functional interactions with numerous proteins that determine their regulation, scaffolding, trafficking, as well as their effects on the downstream cellular processes. Such interactions also compartmentalize the Ca2+ signals arising from TRPC channels. A large number of studies demonstrate that trafficking is a critical mode by which plasma membrane localization and surface expression of TRPC channels are regulated. This review will provide an overview of intracellular trafficking pathways as well as discuss the current state of knowledge regarding the mechanisms and components involved in trafficking of the seven members of the TRPC family (TRPC1-TRPC7). Published by Elsevier Ltd.

引用

页码：43 / 50

页数：8

共 89 条

[1] Caveolin-1 Assembles Type 1 Inositol 1,4,5-Trisphosphate Receptors and Canonical Transient Receptor Potential 3 Channels into a Functional Signaling Complex in Arterial Smooth Muscle Cells [J].

Adebiyi, Adebowale ;

Narayanan, Damodaran ;

Jaggar, Jonathan H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (06) :4341-4348

[2] Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells [J].

Albert, A. P. ;

Saleh, S. N. ;

Peppiatt-Wildman, C. M. ;

Large, W. A. .

JOURNAL OF PHYSIOLOGY-LONDON, 2007, 583 (01) :25-36

[3] The apical compartment: trafficking pathways, regulators and scaffolding proteins [J].

Altschuler, Y ;

Hodson, C ;

Milgram, SL .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (04) :423-429

[4]

Ambudkar I.S., 2014, CELL CALCIUM

[5]

Ambudkar I.S., 2011, STORE OPERATED CA2 E, P73

[6] TRPC1: The link between functionally distinct store-operated calcium channels [J].

Ambudkar, Indu S. ;

Ong, Hwei Ling ;

Liu, Xibao ;

Bandyopadhyay, Bidhan ;

Cheng, Kwong Tai .

CELL CALCIUM, 2007, 42 (02) :213-223

[7]

Ambudkar Indu S, 2004, Sci STKE, V2004, ppe32, DOI 10.1126/stke.2432004pe32

[8] Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells -: Role in apical Ca2+ influx [J].

Bandyopadhyay, BC ;

Swaim, WD ;

Liu, XB ;

Redman, RS ;

Patterson, RL ;

Ambudkar, IS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (13) :12908-12916

[9] TRPC3 Controls Agonist-stimulated Intracellular Ca2+ Release by Mediating the Interaction between Inositol 1,4,5-Trisphosphate Receptor and RACK1 [J].

Bandyopadhyay, Bidhan C. ;

Ong, Hwei L. ;

Lockwich, Timothy P. ;

Liu, Xibao ;

Paria, Biman C. ;

Singh, Brij B. ;

Ambudkar, Indu S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (47) :32821-32830

[10] TRPC1: store-operated channel and more [J].

Beech, DJ .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2005, 451 (01) :53-60

← 1 2 3 4 5 6 7 8 9 →