Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide alkyne cycloadditions

被引：43
作者：
Brittain, William D. G. [1 ]
Buckley, Benjamin R. [2 ]
Fossey, John S. [1 ]
机构：
[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England
[2] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 97期
关键词：
CLICK CHEMISTRY; ASYMMETRIC CATALYSIS; LIGANDS; COMPLEXES; ALCOHOLS; ENANTIOSELECTIVITY; HYDROSILYLATION; DERIVATIVES; AGENT;
D O I：
10.1039/c5cc04886a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 +/- 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in >= 80% enantiomeric excess (e.e.).
引用
收藏
页码：17217 / 17220
页数：4
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