Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide alkyne cycloadditions

被引：43

作者：

Brittain, William D. G. ^{[1
]}

Buckley, Benjamin R. ^{[2
]}

Fossey, John S. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 97期

关键词：

CLICK CHEMISTRY; ASYMMETRIC CATALYSIS; LIGANDS; COMPLEXES; ALCOHOLS; ENANTIOSELECTIVITY; HYDROSILYLATION; DERIVATIVES; AGENT;

D O I：

10.1039/c5cc04886a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 +/- 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in >= 80% enantiomeric excess (e.e.).

引用

页码：17217 / 17220

页数：4

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