An Efficient One-pot Two-component Protocol for Regio- and Chemoselective Synthesis of 5-Aryloyl-1,3,7,9-tetraalkyl-2,8-dithioxo-2,3,8,9-tetrahydro-1H-pyrano[2,3-d:6,5-d']dipyrimidine-4,6(5H,7H)-diones

被引：16

作者：

Rimaz, Mehdi ^{[1
]}

Rabiei, Hossein ^{[1
]}

Khalili, Behzad ^{[2
]}

Prager, Rolf H. ^{[3
]}

机构：

[1] Payame Noor Univ, Dept Chem, Tehran, Iran

[2] Univ Guilan, Dept Chem, Fac Sci, Rasht, Iran

[3] Flinders Univ S Australia, Sch Chem Phys & Earth Sci, Adelaide, SA 5001, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2014年 / 67卷 / 02期

关键词：

3 COMPONENT SYNTHESIS; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; SULFUR ANALOGS; CHEMISTRY; 4-HYDROXYCOUMARIN; DERIVATIVES; LIBRARIES;

D O I：

10.1071/CH13438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel symmetric fused pyrano[2,3-d]pyrimidine derivatives were synthesized in 75-92 % yield by a one-pot two-component reaction of arylglyoxals and 1,3-dialkyl-2-thiobarbituric acids in ethanol at room temperature. This is the first protocol to be reported for the synthesis of 5-aryloyl-1,3,7,9-tetraalkyl-2,8-dithioxo-2,3,8,9-tetrahydro-1H-pyrano[2,3-d:6,5-d ']dipyrimidine-4,6(5H,7H)-diones and the significant features of the present protocol are simplicity, high yields, a simple isolation procedure, and high chemoselectivity.

引用

页码：283 / 288

页数：6

共 49 条

[1] Pd-assisted multicomponent synthesis of heterocycles [J].