Topoisomerase I and II inhibitors: chemical structure, mechanisms of action and role in cancer chemotherapy

被引：24
作者：
Dezhenkova, L. G. [1 ]
Tsvetkov, V. B. [2 ,3 ]
Shtil, A. A. [4 ]
机构：
[1] Russian Acad Med Sci, GF Gause Inst New Antibiot, Moscow 119021, Russia
[2] Russian Acad Med Sci, AV Topchiev Petrochem Synth Inst, Moscow 119991, Russia
[3] Russian Acad Med Sci, VN Orekhovich Inst Biomed Chem, Moscow 119121, Russia
[4] Russian Acad Med Sci, NN Blokhin Canc Res Ctr, Moscow 115478, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2014年 / 83卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
DOUBLE-STRANDED POLYDEOXYRIBONUCLEOTIDES; MEDIATED DNA CLEAVAGE; FLOW LINEAR DICHROISM; MINOR-GROOVE; AUTOMATED DOCKING; SUPERCOILED DNA; REBECCAMYCIN ANALOGS; MOLECULAR DOCKING; BINDING LIGANDS; CAMPTOTHECIN;
D O I：
10.1070/RC2014v083n01ABEH004363
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The review summarizes and analyzes recent published data on topoisomerase I and II inhibitors as potential antitumour agents. Functions and the mechanism of action of topoisomerases are considered. The molecular mechanism of interactions between low-molecular-weight compounds and these proteins is discussed. Topoisomerase inhibitors belonging to different classes of chemical compounds are systematically covered. Assays for the inhibition of topoisomerases and the possibilities of using the computer-aided modelling for the rational design of novel drugs for cancer chemotherapy are presented.
引用
收藏
页码：82 / 94
页数：13
相关论文
共 129 条
  • [1] In silico footprinting of ligands binding to the minor groove of DNA
    Anthony, NG
    Huchet, G
    Johnston, BF
    Parkinson, JA
    Suckling, CJ
    Waigh, RD
    Mackay, SP
    [J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2005, 45 (06) : 1896 - 1907
  • [2] Bailly C, 2001, METHOD ENZYMOL, V340, P610
  • [3] DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin
    Bailly, C
    Riou, JF
    Colson, P
    Houssier, C
    RodriguesPereira, E
    Prudhomme, M
    [J]. BIOCHEMISTRY, 1997, 36 (13) : 3917 - 3929
  • [4] Protein Kinase CK2 Is a Central Regulator of Topoisomerase I Hyperphosphorylation and Camptothecin Sensitivity in Cancer Cell Lines
    Bandyopadhyay, Keya
    Gjerset, Ruth A.
    [J]. BIOCHEMISTRY, 2011, 50 (05) : 704 - 714
  • [5] Important differences between topoisomerase-I and -II targeting agents
    Banerji, Shantanu
    Los, Marek
    [J]. CANCER BIOLOGY & THERAPY, 2006, 5 (08) : 965 - 966
  • [6] EFFECTS OF ANALOGS OF THE DNA MINOR GROOVE BINDER HOECHST-33258 ON TOPOISOMERASE-II AND TOPOISOMERASE-I MEDIATED ACTIVITIES
    BEERMAN, TA
    MCHUGH, MM
    SIGMUND, R
    LOWN, JW
    RAO, KE
    BATHINI, Y
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1131 (01) : 53 - 61
  • [7] INTERACTION OF RNA POLYMERASE INHIBITOR CHROMOMYCIN WITH DNA
    BEHR, W
    HONIKEL, K
    HARTMANN, G
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1969, 9 (01): : 82 - &
  • [8] Bridewell DJA, 1997, ONCOL RES, V9, P535
  • [9] BRIKENSHTEIN VK, 1984, MOL BIOL+, V18, P1314
  • [10] Structure and mechanism of action of type IA DNA topoisomerases
    Bugreev, D. V.
    Nevinsky, G. A.
    [J]. BIOCHEMISTRY-MOSCOW, 2009, 74 (13) : 1467 - 1481
12345678910