Glucose as an Eco-Friendly Reductant in a One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

被引：15

作者：

dos Santos, Thiago ^{[1
,2
]}

Grundke, Caroline ^{[1
]}

Lucas, Tobias ^{[1
]}

Grossmann, Luca ^{[1
]}

Clososki, Giuliano Cesar ^{[2
]}

Opatz, Till ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Chem, D-55128 Mainz, Germany

[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Biomol Sci, Ave Cafe S-N, BR-14040900 Ribeirao Preto, SP, Brazil

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 41期

基金：

巴西圣保罗研究基金会;

关键词：

Biomass; Carbohydrates; Dihydroquinazolinones; One-pot reactions; Reduction; HIGHLY ENANTIOSELECTIVE SYNTHESIS; AROMATIC NITRO-COMPOUNDS; MEDIATED SYNTHESIS; METAL-FREE; ACID; QUINAZOLINONES; HYDROGENATION; EFFICIENT; CATALYST; ARYLHYDROXYLAMINES;

D O I：

10.1002/ejoc.202000970

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carbohydrates such as glucose are an abundant renewable resource that can be employed in synthetic processes as a source of carbon and/or hydrogen to yield products of high economical and biological impact. Herein, we report a versatile and environmentally friendly protocol for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, a privileged scaffold in medicinal chemistry, based on the use of glucose as an eco-friendly reductant in alkaline aqueous medium. This method can be viewed as a blueprint for the development of further one-pot sequences involving glucose as a reductant.

引用

页码：6429 / 6432

页数：4

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