A Case of Covid-19 Patient with Acute Limb Ischemia and Heparin Resistance

被引：21

作者：

Baccellieri, Domenico ^{[1
]}

Bilman, Victor ^{[1
]}

Apruzzi, Luca ^{[1
]}

Monaco, Fabrizio ^{[2
]}

D'Angelo, Armando ^{[3
]}

Loschi, Diletta ^{[1
]}

Melissano, Germano ^{[1
]}

Chiesa, Roberto ^{[1
]}

机构：

[1] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Dept Vasc Surg, Via Olgettina 60, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Milan, Italy

[3] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Coagulat Serv & Thrombosis Res, Milan, Italy

来源：

ANNALS OF VASCULAR SURGERY | 2020年 / 68卷

关键词：

D O I：

10.1016/j.avsg.2020.06.046

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Heparin resistance is an uncommon phenomenon defined as the need for high-dose unfractionated heparin (UFH) of more than 35,000 IU/day to achieve the target activated partial-thromboplastin time ratio or the failure to achieve the desired activated clotting time after a full UFH dose. This rare phenomenon is being more commonly observed in Covid-19 patients in a hypercoagulable state. We describe a Covid-19 patient confirmed by reverse-transcriptase polymerase chain reaction assay, with acute limb ischemia, who developed heparin resistance. The patient was managed by the departments of vascular surgery, anesthesia and intensive care, and the Coagulation Service and Thrombosis Research from San Raffaele Scientific Institute, Milan, Italy.

引用

页码：88 / 92

页数：5

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