Novel water soluble Schiff base metal complexes: Synthesis, characterization, antimicrobial-, DNA cleavage, and anticancer activity

被引：41
作者：
Shiju, C. [1 ]
Arish, D. [2 ]
Kumaresan, S. [3 ]
机构：
[1] HLL Lifecare Ltd, Corp R&D Ctr, Synthet Prod Div, Akkulam 695017, Trivandrums, India
[2] Alexander Dubcek Univ Trencin, FunGlass, Dept Glass Proc, Studentska 2, Trencin 91150, Slovakia
[3] Manonmaniam Sundaranar Univ, Dept Biotechnol, Tirunelveli 627012, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1221卷
关键词：
Schiff base complexes; Antimicrobial; DNA cleavage; Anticancer; IN-VITRO; BIOLOGICAL-ACTIVITY; COPPER(II); AGENTS; CARBON; ACID; SALICYLALDEHYDE; DERIVATIVES; PALLADIUM; DESIGN;
D O I：
10.1016/j.molstruc.2020.128770
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The Schiff base ligand, 4-nitrobenzaldehyde-glycylglycine (4-NBA-GG) and its Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized and characterized by elemental analysis, mass, NMR, IR, electronic spectra, magnetic moment, molar conductance, ESR, CV, TGA, and powder XRD. All the complexes were found to be soluble in water. According to the spectral analysis, the 4-NBA-GG acts as a tridentate monobasic donor coordinating through the azomethine nitrogen, carboxylato oxygen and deprotonated peptide nitrogen atoms. The geometrical structures of these complexes are found to be octahedral. Antimicrobial studies of the synthesized compounds were evaluated and reported. The DNA cleavage activities were assayed against E. coll. DNA, besides, anticancer activities was also studied towards human Colon Cancer Cells (HCT116) and cervical cancer cell line (HeLa). The obtained results showed that the complexes, especially Cu(II) and Zn(II) complexes strongly interact with E. coli DNA and active against both cancer cells. (C) 2020 Elsevier B.V. All rights reserved.
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页数：8
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