Allergy Work-Up Including Component-Resolved Diagnosis How to Make Allergen-Specific Immunotherapy More Specific

被引：30

作者：

Kleine-Tebbe, Joerg ^{[1
]}

Matricardi, Paolo M. ^{[2
]}

Hamilton, Robert G. ^{[3
]}

机构：

[1] Outpatient Clin Hanf Ackermann & Kleine Tebbe, Allergy & Asthma Ctr Westend, D-14050 Berlin, Germany

[2] Charite, Dept Pediat Pneumol & Immunol, AG Mol Allergol & Immunomodulat, D-13353 Berlin, Germany

[3] Johns Hopkins Univ, Sch Med, Johns Hopkins Asthma & Allergy Ctr, Johns Hopkins Dermatol Allergy & Clin Immunol Ref, Baltimore, MD 21224 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 01期

关键词：

Allergen-specific immunotherapy; Allergy diagnosis; Component-resolved diagnosis; Pollen pan-allergen; Profilin; Polcalcin; Major allergen; MOLECULAR DIAGNOSIS; PHLEUM-PRATENSE; IGE; CHILDREN; GRASS; PRESCRIPTION; EFFICACY; RHINITIS; SAFETY;

D O I：

10.1016/j.iac.2015.08.012

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Symptoms are recorded by obtaining a clinical history. Allergen sensitization is demonstrated by skin prick test or allergen-specific IgE serology. IgE sensitizations to allergen sources can be identified knowing the relationship between major aeroallergens and homologous allergen families. Some develop allergic sensitization to pan-allergens. Then allergen extracts do not allow definitive separation of the sources, but IgE antibody detection with major allergenic molecules facilitates differentiation of sensitizing allergen sources. IgE sensitizations to inhalant allergens are only relevant in case of corresponding symptoms. In questionable cases, conjunctival or nasal provocation tests help induce confirmatory symptoms and identify relevant allergens for immunotherapy.

引用

页码：191 / +

页数：14

共 29 条

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