Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats

被引：11
作者：
Mu, Xin [1 ,2 ]
Yuan, Xia [3 ]
Du, Li-Da [4 ]
He, Guo-Rong [1 ,2 ]
Du, Guan-Hua [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[4] Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2016年 / 18卷 / 01期
关键词：
quercetin; Parkinson's disease; 6-hydroxydopamine; tremor; SUBTHALAMIC NUCLEUS; NEURONAL-ACTIVITY; DOPAMINE; MOVEMENT; MODELS;
D O I：
10.1080/10286020.2015.1057576
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Quercetin, a flavonoid present in many plants, is reported to be effective in models of neurodegenerative diseases. The aim of the present study was to evaluate the anti-tremor effects of quercetin in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. In rats, quercetin had no effect on apomorphine-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA lesioned rats. Interestingly, quercetin could decrease the burst frequency in a dose- and time-dependent manner. These results suggest that quercetin may have a protective effect on models to mimic muscle tremors of Parkinson's disease. This effect of quercetin may be associated with serotonergic system, but further study is needed.
引用
收藏
页码：65 / 71
页数：7
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