Heterocyclic Compounds Derivatives Inhibit Human Prostate Cancer Cells

被引：0
作者：
Yu, Wang-Hai [1 ]
Song, Li-De [1 ]
Zhu, Ling-Fei [1 ]
机构：
[1] Zhuji Peoples Hosp Zhejiang Prov, Dept Urol, Zhuji, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2018年 / 37卷 / 06期
关键词：
organic heterocyclic; prostate cancer; X-ray crystallography; DIHYDROPYRAN DERIVATIVES; ANTIBACTERIAL ACTIVITIES; BISCOUMARIN;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of novel organic heterocyclic compounds (1-6) were synthesized with the aim of using them as anti-cancer agents in prostate cancer, and their structures were characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. Their anti-cancer activity against four human prostate cancer cells including PC3, VCaP, LNCap and DU145 were evaluated in vitro using the MTT assay, and the results showed that compounds 4-6 had more efficient anti-cancer activity against the four cancer cell lines, and compounds 1-3 did not show any inhibition.
引用
收藏
页码：1120 / 1124
页数：5
相关论文
共 10 条
[1]  
[Anonymous], 1997, SHELXL 97 PROGRAM CR
[2]   High concentrations of fatty acids and β-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows [J].
Du, Xiliang ;
Zhu, Yiwei ;
Peng, Zhicheng ;
Cui, Yuanxu ;
Zhang, Qiang ;
Shi, Zhen ;
Guan, Yuan ;
Sha, Xueying ;
Shen, Taiyu ;
Yang, Yuchen ;
Li, Xiaobing ;
Wang, Zhe ;
Li, Xinwei ;
Liu, Guowen .
JOURNAL OF DAIRY SCIENCE, 2018, 101 (04) :3476-3487
[3]   Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows [J].
Du, Xiliang ;
Shi, Zhen ;
Peng, Zhicheng ;
Zhao, Chenxu ;
Zhang, Yuming ;
Wang, Zhe ;
Li, Xiaobing ;
Liu, Guowen ;
Li, Xinwei .
JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (12) :3296-3308
[4]   Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives [J].
Li, Jing ;
Xue, Xiao-yan ;
Li, Xia ;
Hou, Zheng ;
Yang, Xiao-hui ;
Qu, Di ;
Zhou, Ying ;
Zhang, Zi-dan ;
Luo, Xiao-xing ;
Li, Jiang-tao ;
Li, Ming-kai .
ARCHIVES OF PHARMACAL RESEARCH, 2016, 39 (10) :1349-1355
[5]   Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities [J].
Li, Jing ;
Sui, Yun-Peng ;
Xin, Jia-Jia ;
Du, Xin-Liang ;
Li, Jiang-Tao ;
Huo, Hai-Ru ;
Ma, Hai ;
Wang, Wei-Hao ;
Zhou, Hai-Yu ;
Zhan, Hong-Dan ;
Wang, Zhu-Ju ;
Li, Chun ;
Sui, Feng ;
Li, Xia .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (23) :5520-5523
[6]   Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity [J].
Li, Jing ;
Lv, Chang-Wei ;
Li, Xiao-Jun ;
Qu, Di ;
Hou, Zheng ;
Jia, Min ;
Luo, Xiao-Xing ;
Li, Xia ;
Li, Ming-Kai .
MOLECULES, 2015, 20 (09) :17469-17482
[7]   Synthesis, photoluminescent, antibacterial activities and theoretical studies of 4-hydroxycoumarin derivatives [J].
Li, Jing ;
Hou, Zheng ;
Li, Fen ;
Zhang, Zi-dan ;
Zhou, Ying ;
Luo, Xiao-xing ;
Li, Ming-kai .
JOURNAL OF MOLECULAR STRUCTURE, 2014, 1075 :509-514
[8]   Synthesis, antibacterial activities, and theoretical studies of dicoumarols [J].
Li, Jing ;
Hou, Zheng ;
Chen, Guang-Hui ;
Li, Fen ;
Zhou, Ying ;
Xue, Xiao-Yan ;
Li, Zhou-Peng ;
Jia, Min ;
Zhang, Zi-Dan ;
Li, Ming-Kai ;
Luo, Xiao-Xing .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 12 (29) :5528-5535
[9]   β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway [J].
Song, Yuxiang ;
Li, Na ;
Gu, Jingmin ;
Fu, Shoupeng ;
Peng, Zhicheng ;
Zhao, Chenxu ;
Zhang, Yuming ;
Li, Xiaobing ;
Wang, Zhe ;
Li, Xinwei ;
Liu, Guowen .
JOURNAL OF DAIRY SCIENCE, 2016, 99 (11) :9184-9198
[10]   Histamine Induces Bovine Rumen Epithelial Cell Inflammatory Response via NF-κB Pathway [J].
Sun, Xudong ;
Yuan, Xue ;
Chen, Liang ;
Wang, Tingting ;
Wang, Zhe ;
Sun, Guoquan ;
Li, Xiaobing ;
Li, Xinwei ;
Liu, Guowen .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 42 (03) :1109-1119
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