Dietary fibers reduce obesity-related disorders: mechanisms of action

被引:66
作者
Dayib, Miski [1 ]
Larson, Jacob [1 ]
Slavin, Joanne [1 ]
机构
[1] Univ Minnesota Twin Cities, Dept Food Sci & Nutr, 1334 Eckles Ave, St Paul, MN 55108 USA
关键词
dietary fiber; gut microbiota; obesity; short-chain fatty acids; GUT MICROBIOME; PREBIOTICS; WHOLE;
D O I
10.1097/MCO.0000000000000696
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Dietary fibers decrease risk of cardiovascular disease and obesity, but the most important mechanisms for fiber's protective properties are debated. The purpose of the review is to summarize the recent human studies that examine mechanisms how dietary fiber decreases risk of obesity-related disorders. Recent findings Dietary fiber has effects throughout the digestive tract that decrease risk of obesity-related diseases. Soluble, viscous fibers slow absorption of and decrease serum cholesterol. Intake of dietary fiber enhances satiety and reduces food intake at future meals. The importance of gut fermentation and changes in the gut microbiota and metabolites are linked to decrease risk for obesity-related disorders. Dietary fibers alter the gut microbiota and produce metabolites such as short-chain fatty acids that may explain fiber's role in obesity prevention and treatment. Dietary fiber encompasses many plant compounds, so conclusions that dietary fiber reduces or treats obesity-related disorders must be considered by the fiber was fed in the study. Dietary fiber prevents and treats obesity-related disorders. Mechanisms for this protection include decreased absorption of macronutrients and enhanced satiety. Changes in the gut microbiota and short-chain fatty acids are emerging mechanisms to explain why high fiber diets protect against obesity and have a role in obesity treatment.
引用
收藏
页码:445 / 450
页数:6
相关论文
共 23 条
[1]   Gut microbial metabolites in obesity, NAFLD and T2DM [J].
Canfora, Emanuel E. ;
Meex, Ruth C. R. ;
Venema, Koen ;
Blaak, Ellen E. .
NATURE REVIEWS ENDOCRINOLOGY, 2019, 15 (05) :261-273
[2]   Health Effects and Sources of Prebiotic Dietary Fiber [J].
Carlson, Justin L. ;
Erickson, Jennifer M. ;
Lloyd, Beate B. ;
Slavin, Joanne L. .
CURRENT DEVELOPMENTS IN NUTRITION, 2018, 2 (03)
[3]   Nutritional interest of dietary fiber and prebiotics in obesity: Lessons from the MyNewGut consortium [J].
Delzenne, Nathalie M. ;
Olivares, Marta ;
Neyrinck, Audrey M. ;
Beaumont, Martin ;
Kjolbaek, Louise ;
Larsen, Thomas Meinert ;
Benitez-Paez, Alfonso ;
Romani-Perez, Marina ;
Garcia-Campayo, Vicenta ;
Bosscher, Douwina ;
Sanz, Yolanda ;
van der Kamp, Jan-Willem .
CLINICAL NUTRITION, 2020, 39 (02) :414-424
[4]   Gastrointestinal Effects of Low-Digestible Carbohydrates [J].
Grabitske, Hollie A. ;
Slavin, Joanne L. .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2009, 49 (04) :327-360
[5]  
Howlett JF, FOOD NUTR RES, DOI [10.3402/fnr.v5410.5759, DOI 10.3402/FNR.V5410.5759]
[6]   Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease [J].
Kaye, David M. ;
Shihata, Waled A. ;
Jama, Hamdi A. ;
Tsyganov, Kirill ;
Ziemann, Mark ;
Kiriazis, Helen ;
Horlock, Duncan ;
Vijay, Amrita ;
Giam, Beverly ;
Vinh, Antony ;
Johnson, Chad ;
Fiedler, April ;
Donner, Daniel ;
Snelson, Matthew ;
Coughlan, Melinda T. ;
Phillips, Sarah ;
Du, Xiao-Jun ;
El-Osta, Assam ;
Drummond, Grant ;
Lambert, Gavin W. ;
Spector, Tim D. ;
Valdes, Ana M. ;
Mackay, Charles R. ;
Marques, Francine Z. .
CIRCULATION, 2020, 141 (17) :1393-1403
[7]   Effect of whole-grain consumption on changes in fecal microbiota: a review of human intervention trials [J].
Koecher, Katie J. ;
McKeown, Nicola M. ;
Sawicki, Caleigh M. ;
Menon, Ravi S. ;
Slavin, Joanne L. .
NUTRITION REVIEWS, 2019, 77 (07) :487-497
[8]   Microbial ecology - Human gut microbes associated with obesity [J].
Ley, Ruth E. ;
Turnbaugh, Peter J. ;
Klein, Samuel ;
Gordon, Jeffrey I. .
NATURE, 2006, 444 (7122) :1022-1023
[9]   Nondigestible Oligosaccharides with Anti-Obesity Effects [J].
Liu, Yongjian ;
Chen, Jiajia ;
Tan, Qiuhua ;
Deng, Xiaoyi ;
Tsa, Ping-Ju ;
Chen, Pei-Hsuan ;
Ye, Manxiang ;
Guo, Jiao ;
Su, Zhengquan .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 68 (01) :4-16
[10]   Food processing, gut microbiota and the globesity problem [J].
Miclotte, Lisa ;
Van de Wiele, Tom .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2020, 60 (11) :1769-1782