In Situ Generation and Diels-Alder Reaction of Benzynes Derivatives with 5-Membered Ring Heterocycles Using a Microcapillary Flow Reactor

被引：12

作者：

Khadra, Abir ^{[1
]}

Organ, Michael G. ^{[1
,2
,3
]}

机构：

[1] York Univ, Dept Chem, 4700 Keele St, Toronto, ON M3J 1P3, Canada

[2] Univ Ottawa, CCRI, Ottawa, ON K1N 6N5, Canada

[3] Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON K1N 6N5, Canada

来源：

JOURNAL OF FLOW CHEMISTRY | 2016年 / 6卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

flow; benzyne; Diels-Alder; reactive; intermediate; 2-SUBSTITUTED FURANS; REGIOSELECTIVITY; ARYNES;

D O I：

10.1556/1846.2016.00034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The formation of benzynes derivatives from ortho-trimethylsilyl triflates using tetra-n-butylammonium fluoride (TBAF) as the benzyne-forming trigger was achieved in a straightforward flow reactor at room temperature. These benzynes were immediately trapped in Diels-Alder reactions to deliver the desired cycloadducts.

引用

页码：293 / 296

页数：4

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