Evaluation of anticholinesterase effect of some Epilobium species and quantification of hyperoside by HPLC

被引：7

作者：

Karakaya, Songul ^{[1
]}

Suntar, Ipek ^{[2
]}

Aydin, Bilge ^{[3
]}

Dursunoglu, Benan ^{[1
]}

Gozcu, Sefa ^{[3
]}

Senol, Onur ^{[4
]}

Bayrak, Burak ^{[4
]}

Ozbek, Hilal ^{[1
]}

Koca, Mehmet ^{[5
]}

Ceribasi, Songul ^{[6
]}

Yakinci, Omer Faruk ^{[2
,7
]}

Guvenalp, Zuhal ^{[1
]}

Kadioglu, Yucel ^{[4
]}

机构：

[1] Ataturk Univ, Fac Pharm, Dept Pharmacognosy, Erzurum, Turkey

[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, Ankara, Turkey

[3] Binali Yildirim Univ, Fac Pharm, Dept Pharmacognosy, Erzincan, Turkey

[4] Ataturk Univ, Fac Pharm, Dept Analyt Chem, Erzurum, Turkey

[5] Ataturk Univ, Fac Pharm, Dept Pharmaceut Chem, Erzurum, Turkey

[6] Firat Univ, Fac Vet Med, Dept Pathol, Elazig, Turkey

[7] Minist Hlth, Natl Poison Informat Serv, Ankara, Turkey

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 05期

关键词：

Anatomy; anticholinesterase; Epilobium; hyperoside; Onagraceae;

D O I：

10.1080/14786419.2020.1856841

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This article presents the evaluation of anticholinesterase effects of aerial parts of Epilobium angustifolium, E. stevenii and E. hirsutum and isolated flavonoids from E. angustifolium, and quantification of the flavonoids by HPLC. Besides, the highest acetylcholinesterase inhibition was seen in the EtOAc sub-extracts of E. angustifolium and E. stevenii (36.51 +/- 1.88 and 39.89 +/- 3.09%, respectively), whereas EtOAc sub-extract of E. angustifolium had the best butyrylcholinesterase inhibition (62.09 +/- 1.98%). Hyperoside showed strong inhibition activity on both enzymes. The active EtOAc sub-extract of E. angustifolium was quantitatively analyzed for their content of hyperoside (quercetin-3-O-beta-D-galactoside) by HPLC. The content of hyperoside in EtOAc sub-extract of E. angustifolium was detected as 3.312%. The anatomical structures of the stem, leaf, sepal, petal, anther, and filament of E. angustifolium were investigated. The anatomical properties given in this study provide a description of E. angustifolium.

引用

页码：1296 / 1299

页数：4

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