Radical Alkynyltrifluoromethylation of Alkenes Initiated by an Electron Donor-Acceptor Complex

被引：118

作者：

Jiang, Heng ^{[1
]}

He, Yanyan ^{[1
]}

Cheng, Yuanzheng ^{[1
]}

Yu, Shouyun ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem, Nanjing 210023, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; TRIFLONE CHEMISTRY; LIGHT-IRRADIATION; ORGANIC-SYNTHESIS; VINYL SULFONES; ALKYNYLATION; ALKYLATION; TRIFLUOROMETHYLALKYNYLATION; ALLYLATION; DRIVEN;

D O I：

10.1021/acs.orglett.7b00337

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radical alkynyltrifluoromethylation of alkenes with actylenic triflones has been achieved. This radical chain reaction is initiated by a catalytic amount of an electron-donor acceptor complex composed of Togni's reagent and N-methylmorpholine. This transformation proceeds under exceptionally mild and operationally simple conditions. A variety of alkenes are compatible in this protocol including aliphatic alkenes, vinyl ethers, enecarbamates, styrenes, and even acrylates, providing diverse, beta-trifluoromethyl alkynes in good to excellent yields.

引用

页码：1240 / 1243

页数：4

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