Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/B) from Men Who Have Sex with Men in Guangxi Zhuang Autonomous Region, China

被引：3
作者：
Li, Kang [1 ,2 ,3 ]
Liu, Meiliang [1 ,2 ]
Li, Jianjun [4 ]
Dong, Aaobo [3 ]
Zhou, Yuxi [1 ,2 ]
Ding, Yibo [3 ]
Liang, Yanling [1 ,2 ,3 ]
Shao, Yiming [1 ,2 ,3 ]
机构：
[1] Guangxi Med Univ, Sch Publ Hlth, Guangxi Key Lab Aids Prevent & Treatment, Nanning, Peoples R China
[2] Guangxi Med Univ, Sch Publ Hlth, Guangxi Univ Key Lab Prevent & Control Highly Pre, Nanning, Peoples R China
[3] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, 155 Changbai Rd, Beijing 102206, Peoples R China
[4] Guangxi Ctr Dis Prevent & Control, Nanning, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2019年 / 35卷 / 10期
基金：
中国国家自然科学基金;
关键词：
HIV-1; recombinant; CRF01_AE; B; MSM; Guangxi; China; INFECTION; TYPE-1;
D O I：
10.1089/aid.2019.0149
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report here a novel HIV-1 recombinant form (18GXD4705) composed of CRF01_AE and subtype B, acquired from an unmarried HIV-positive young man subject infected through homosexual contact in Guangxi Province of eastern China. The phylogenetic analysis of the near full-length genome of 18GXD4705 indicated that one subtype B segment was inserted into the CRF01_AE backbone, with one recombinant breakpoint demonstrated in the pol region. The CRF01_AE region (I and III) of recombinant correlated with a previously reported subcluster 4 lineage. The B subregions (II) are greatly clustered together, with B strain references. The continued generation of this novel recombinant increases the genetic complexity and diversity of the HIV epidemic in Guangxi. In addition, further molecular epidemiological investigations should be conducted to continuously monitor the dynamic transmission of HIV-1 in the region.
引用
收藏
页码：972 / 977
页数：6
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