Synthesis of potentially anti-inflammatory IPL576,092-contignasterol and IPL576,092-manoalide hybrids

被引：14

作者：

Izzo, I

Avallone, E

Della Monica, C

Casapullo, A

Amigo, M

De Riccardis, F

机构：

[1] Univ Salerno, Dipartimento Chim, I-84081 Baronissi, SA, Italy

[2] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

[3] Univ Valencia, Fac Farm, Dept Farmacol, E-46100 Burjassot, Valencia, Spain

来源：

TETRAHEDRON | 2004年 / 60卷 / 26期

关键词：

IPL576,092; contignasterol; manoalide; steroids; anti-inflammatory compounds;

D O I：

10.1016/j.tet.2004.04.084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two potentially anti-inflammatory steroidal hybrid compounds has been accomplished through a 16- and 17-step sequence, respectively, starting from commercially available androst-5-en-3beta-ol-17-one. The synthetic strategies are based both on stereoselective side chains elaboration and high yielding functional group transformations. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5587 / 5593

页数：7