Microglia and astrocyte dysfunction in parkinson's disease

被引：243

作者：

Kam, Tae-In ^{[1
,2
,3
]}

Hinkle, Jared T. ^{[4
]}

Dawson, Ted M. ^{[1
,2
,3
,4
,5
]}

Dawson, Valina L. ^{[1
,2
,3
,4
,6
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Neuroregenerat Program, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Stem Cell Program, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA

来源：

NEUROBIOLOGY OF DISEASE | 2020年 / 144卷

关键词：

Microglia; Astrocyte; Glia; Neuroinflammation; Neurodegeneration; Parkinson's disease; Neurodegenerative disease; NLRP3 INFLAMMASOME ACTIVATION; QUALITY-CONTROL MECHANISMS; DJ-1; KNOCK-DOWN; REPEAT KINASE 2; NF-KAPPA-B; ALPHA-SYNUCLEIN; DOPAMINERGIC NEURODEGENERATION; ALZHEIMERS-DISEASE; SIGNALING PROTEIN; LRRK2; EXPRESSION;

D O I：

10.1016/j.nbd.2020.105028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.

引用

页数：10

共 187 条

[1] A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease [J].

Aflaki, Elma ;

Stubblefield, Barbara K. ;

McGlinchey, Ryan P. ;

McMahon, Benjamin ;

Ory, Daniel S. ;

Sidransky, Ellen .

NEUROBIOLOGY OF DISEASE, 2020, 134

[2] Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages [J].

Aflaki, Elma ;

Moaven, Nima ;

Borger, Daniel K. ;

Lopez, Grisel ;

Westbroek, Wendy ;

Chae, Jae Jin ;

Marugan, Juan ;

Patnaik, Samarjit ;

Maniwang, Emerson ;

Gonzalez, Ashley N. ;

Sidransky, Ellen .

AGING CELL, 2016, 15 (01) :77-88

[3] Astrocyte-neuron metabolic relationships: for better and for worse [J].

Allaman, Igor ;

Belanger, Mireille ;

Magistretti, Pierre J. .

TRENDS IN NEUROSCIENCES, 2011, 34 (02) :76-87

[4] Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation [J].

Antunes Dionisio, Pedro Eloi ;

Oliveira, Sara Rodrigues ;

Jose Dias Amaral, Joana Sao ;

Pereira Rodrigues, Cecilia Maria .

MOLECULAR NEUROBIOLOGY, 2019, 56 (04) :2990-3004

[5] Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain [J].

Askew, Katharine ;

Li, Kaizhen ;

Olmos-Alonso, Adrian ;

Garcia-Moreno, Fernando ;

Liang, Yajie ;

Richardson, Philippa ;

Tipton, Tom ;

Chapman, Mark A. ;

Riecken, Kristoffer ;

Beccari, Sol ;

Sierra, Amanda ;

Molnar, Zoltan ;

Cragg, Mark S. ;

Garaschuk, Olga ;

Perry, V. Hugh ;

Gomez-Nicola, Diego .

CELL REPORTS, 2017, 18 (02) :391-405

[6] LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients [J].

Atashrazm, Farzaneh ;

Hammond, Deborah ;

Perera, Gayathri ;

Bolliger, Marc F. ;

Matar, Elie ;

Halliday, Glenda M. ;

Schule, Birgitt ;

Lewis, Simon J. G. ;

Nichols, R. Jeremy ;

Dzamko, Nicolas .

MOVEMENT DISORDERS, 2019, 34 (03) :406-415

[7] The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease [J].

Bandopadhyay, R ;

Kingsbury, AE ;

Cookson, MR ;

Reid, AR ;

Evans, IM ;

Hope, AD ;

Pittman, AM ;

Lashley, T ;

Canet-Aviles, R ;

Miller, DW ;

McLendon, C ;

Strand, C ;

Leonard, AJ ;

Abou-Sleiman, PM ;

Healy, DG ;

Ariga, H ;

Wood, NW ;

de Silva, R ;

Revesz, T ;

Hardy, JA ;

Lees, AJ .

BRAIN, 2004, 127 :420-430

[8] Genetics of Parkinson's disease: An introspection of its journey towards precision medicine [J].

Bandres-Ciga, Sara ;

Diez-Fairen, Monica ;

Jeff Kim, Jonggeol ;

Singleton, Andrew B. .

NEUROBIOLOGY OF DISEASE, 2020, 137

[9] LONG-TERM POLARIZATION OF MICROGLIA UPON α-SYNUCLEIN OVEREXPRESSION IN NONHUMAN PRIMATES [J].

Barkholt, P. ;

Sanchez-Guajardo, V. ;

Kirik, D. ;

Romero-Ramos, M. .

NEUROSCIENCE, 2012, 208 :85-96

[10] Identification of region-specific astrocyte subtypes at single cell resolution [J].

Batiuk, Mykhailo Y. ;

Martirosyan, Araks ;

Wahis, Jerome ;

de Vin, Filip ;

Marneffe, Catherine ;

Kusserow, Carola ;

Koeppen, Jordan ;

Viana, Joao Filipe ;

Oliveira, Joao Filipe ;

Voet, Thierry ;

Ponting, Chris P. ;

Belgard, T. Grant ;

Holt, Matthew G. .

NATURE COMMUNICATIONS, 2020, 11 (01)

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