Multifocal vasculopathy due to varicella-zoster virus (VZV): Serial analysis of VZV DNA and intrathecal synthesis of VZV antibody in cerebrospinal fluid

被引：13

作者：

Kronenberg, A ^{[1
]}

Schupbach, R

Schuknecht, B

Bossart, W

Weber, R

Gilden, DH

Speck, RF

机构：

[1] Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland

[2] Univ Zurich Hosp, Dept Internal Med, CH-8091 Zurich, Switzerland

[3] Univ Zurich Hosp, Inst Neuroradiol, CH-8091 Zurich, Switzerland

[4] Univ Zurich Hosp, Inst Med Virol, CH-8091 Zurich, Switzerland

[5] Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA

[6] Univ Colorado, Hlth Sci Ctr, Dept Microbiol, Denver, CO 80262 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2002年 / 35卷 / 03期

关键词：

D O I：

10.1086/341492

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition of multifocal vasculopathy due to varicella-zoster virus (VZV) is often problematic. We describe a human immunodeficiency virus-infected patient who had progressive central nervous system disease for >3 months. Both VZV DNA and antibody were detected in cerebrospinal fluid (CSF) specimens; serial polymerase chain reaction analyses confirmed the diagnosis and guided the duration of therapy. Reduced ratios of VZV antibody in serum to that in CSF were also demonstrated.

引用

页码：330 / 333

页数：4

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