Effect of fish and olive oil on mitochondrial ATPase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b

被引：12

作者：

Torres-Sanchez, Erandis D. ^{[1
]}

Pacheco-Moises, Fermin P. ^{[2
]}

Macias-Islas, Miguel A. ^{[3
]}

Morales-Sanchez, Eddic W. ^{[1
]}

Ramirez-Ramirez, Viridiana ^{[1
]}

Celis de la Rosa, Alfredo J. ^{[4
]}

Cid-Hernandez, Margarita ^{[2
]}

Sorto-Gomez, Tanya E. ^{[1
]}

Ortiz, Genaro G. ^{[1
]}

机构：

[1] Mexican Inst Social Secur IMSS, WBRC, Neurosci Dept, Lab Dev Aging Neurodegenerat Dis, Guadalajara, Jalisco, Mexico

[2] Univ Guadalajara, Ctr Exact Sci & Engn, Dept Chem, Lab Biochem, Guadalajara, Jalisco, Mexico

[3] Univ Guadalajara, Hlth Sci Ctr, Dept Pharmacol, Guadalajara, Jalisco, Mexico

[4] Univ Guadalajara, Hlth Sci Ctr, Publ Dept, Guadalajara, Jalisco, Mexico

来源：

NUTRICION HOSPITALARIA | 2018年 / 35卷 / 01期

关键词：

Maple sclerosis; Mitochondrial ATPase; Membranel fluidity; Olive oil; Fish oil; POLYUNSATURATED FATTY-ACIDS; INFLAMMATION; DYSFUNCTION; SYNTHASE; RISK;

D O I：

10.20960/nh.1084

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS). Objective: To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement. Methods: Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified. Results: In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized. Conclusion: The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS.

引用

页码：162 / 168

页数：7

共 32 条

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