Monitoring of cell cultures with LTCC microelectrode array

被引：24

作者：

Ciosek, P. ^{[1
]}

Zawadzki, K. ^{[1
]}

Lopacinska, J. ^{[1
]}

Skolimowski, M. ^{[1
]}

Bembnowicz, P. ^{[2
]}

Golonka, L. J. ^{[2
]}

Brzozka, Z. ^{[1
]}

Wroblewski, W. ^{[1
]}

机构：

[1] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland

[2] Wroclaw Univ Technol, Fac Microsyst Elect & Photon, PL-50370 Wroclaw, Poland

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2009年 / 393卷 / 08期

关键词：

Sensor array; Cell cultures; LTCC; Ion-selective electrodes; POTENTIOMETRIC ELECTRONIC TONGUE; BIOLOGICAL CELLS; STEM-CELLS; TISSUE; RECOGNITION; SENSOR; TECHNOLOGIES; GROWTH;

D O I：

10.1007/s00216-009-2651-x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells. Noninvasive monitoring performed with the LTCC microelectrode array can be applied for future cell-engineering purposes.

引用

收藏

页码：2029 / 2038

页数：10

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