The within-host viral kinetics of SARS-CoV-2

被引：70
作者：
Li, Chentong [1 ]
Xu, Jinhu [2 ]
Liu, Jiawei [3 ]
Zhou, Yicang [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Math & Stat, Xian 710049, Peoples R China
[2] Xian Univ Technol, Sch Sci, Xian 710048, Peoples R China
[3] Univ Chicago, Dept Ecol & Evolut, 940 E 57Th St, Chicago, IL 60637 USA
来源：
MATHEMATICAL BIOSCIENCES AND ENGINEERING | 2020年 / 17卷 / 04期
基金：
中国国家自然科学基金;
关键词：
SARS-CoV-2; MERS; di fferential equation model; basic reproductive number; ADAPTIVE IMMUNE-RESPONSE; MODELS;
D O I：
10.3934/mbe.2020159
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this work, we use a within-host viral dynamic model to describe the SARS-CoV-2 kinetics in the host. Chest radiograph score data are used to estimate the parameters of that model. Our result shows that the basic reproductive number of SARS-CoV-2 in host growth is around 3.79. Using the same method we also estimate the basic reproductive number of MERS virus is 8.16 which is higher than SARS-CoV-2. The PRCC method is used to analyze the sensitivities of model parameters. Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model.
引用
收藏
页码：2853 / 2861
页数：9
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