Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD

被引：340

作者：

Kuriyan, Ajay E. ^{[1
,3
]}

Albini, Thomas A. ^{[1
]}

Townsend, Justin H. ^{[1
]}

Rodriguez, Marianeli ^{[1
]}

Pandya, Hemang K. ^{[4
]}

Leonard, Robert E., II ^{[4
]}

Parrott, M. Brandon ^{[2
]}

Rosenfeld, Philip J. ^{[1
]}

Flynn, Harry W., Jr. ^{[1
]}

Goldberg, Jeffrey L. ^{[5
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Ophthalmol, Bascom Palmer Eye Inst, Miami, FL 33136 USA

[2] Ctr Sight, Sarasota, FL USA

[3] Univ Rochester, Med Ctr, Dept Ophthalmol, Flaum Eye Inst, Rochester, NY 14642 USA

[4] Univ Oklahoma, Dept Ophthalmol, Dean McGee Eye Inst, Oklahoma City, OK USA

[5] Stanford Univ, Byers Eye Inst, Dept Ophthalmol, Palo Alto, CA 94304 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2017年 / 376卷 / 11期

基金：

美国国家卫生研究院;

关键词：

IN-VITRO DIFFERENTIATION; OPTIC-NERVE DISEASES; MACULAR DEGENERATION; OPHTHALMOLOGY TREATMENT; CLINICS; INTERVENTIONS; FDA; THERAPIES; SCOTS;

D O I：

10.1056/NEJMoa1609583

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue-derived "stem cells"have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells"at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients' visual acuity ranged from 20/200 to no light perception.

引用

页码：1047 / 1053

页数：7

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