Photoacoustic tomography of vascular compliance in humans

被引：20

作者：

Hai, Pengfei ^{[1
]}

Zhou, Yong ^{[1
]}

Liang, Jinyang ^{[1
]}

Li, Chiye ^{[1
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, Opt Imaging Lab, St Louis, MO 63130 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2015年 / 20卷 / 12期

基金：

美国国家卫生研究院;

关键词：

photoacoustic tomography; vascular elasticity; vascular compliance; thrombosis; INTRAVASCULAR ULTRASOUND ELASTOGRAPHY; OPTICAL COHERENCE ELASTOGRAPHY; BIOLOGICAL TISSUES; MICROSCOPY; RESOLUTION; ELASTICITY;

D O I：

10.1117/1.JBO.20.12.126008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure blood vessel compliance in humans. Implemented on a linear-arraybased photoacoustic computed tomography system, VE-PAT can quantify blood vessel compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused blood vessel phantoms and quantifying their compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the compliances of blood vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess blood vessel compliance in a human subject. Experimental results showed a decrease in compliance when an occlusion occurred downstream from the measurement point in the blood vessels, demonstrating VE-PAT's potential for clinical thrombosis detection. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

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