New and Efficient Iron Halide Mediated Synthesis of Alkenyl Halides through Coupling of Alkynes and Alcohols

被引:52
作者
Biswas, Srijit [1 ]
Maiti, Sukhendu [1 ]
Jana, Umasish [1 ]
机构
[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India
关键词
Alkenyl halides; Alkynes; Alcohols; Iron; Sustainable chemistry; CARBON BOND FORMATION; C-H INSERTION; ALLYLIC ALCOHOLS; NUCLEOPHILIC-SUBSTITUTION; STEREOSELECTIVE-SYNTHESIS; CATALYZED ALLYLATION; VINYL BROMIDES; TRIPLE BONDS; ARYL; CONSTRUCTION;
D O I
10.1002/ejoc.200900104
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel, simple, and straightforward one-pot reaction of alkynes with various alcohols in the presence of iron salts (FeCl3 and FeBr3) was described to yield the corresponding alkenyl halides with complete regioselectivity and high stereoselectivity. The reaction is high yielding and works under mild conditions. The iron salts act as Lewis acids and a source of halides, The reaction tolerates a wide variety of functional groups. Noteworthy is that this method is cheap, efficient, and environmentally friendly. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
引用
收藏
页码:2354 / 2359
页数:6
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