Palladium-catalyzed [5+2] oxidative annulation of N-Arylhydrazones with alkynes through C-H activation to synthesize Benzo[d][1,2]diazepines

被引：17
|
作者：
Asamdi, Manjoorahmed [1 ]
Shaikh, Mohammedumar M. [1 ]
Chauhan, Prakashsingh M. [1 ]
Chikhalia, Kishor H. [2 ]
机构：
[1] Gujarat Univ, Dept Chem, Ahmadabad 380009, Gujarat, India
[2] Veer Narmad South Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India
来源：
TETRAHEDRON | 2018年 / 74卷 / 27期
关键词：
Pd catalyst; 5+2] annulation; C-H activation; Alkyne; Palladacycle; OH BOND ACTIVATION; STEREOSELECTIVE-SYNTHESIS; ANTI-HIV-1; ACTIVITY; EFFICIENT SYNTHESIS; COUPLING REACTION; TIBO DERIVATIVES; FUNCTIONALIZATION; TOSYLHYDRAZONES; CONSTRUCTION; HETEROCYCLES;
D O I：
10.1016/j.tet.2018.05.051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and novel method using palladium catalyst for the synthesis of benzo[d][1,2]diazepines by [5 + 2] annulation of N-arylhydrazones with alkynes has been developed. This methodology undergoes through eight membered palladacycle serving as a backbone for the formation of C-C/C-N bond to provide benzodiazepine derivatives in moderate to good yield. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3719 / 3727
页数：9
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