Palladium-catalyzed [5+2] oxidative annulation of N-Arylhydrazones with alkynes through C-H activation to synthesize Benzo[d][1,2]diazepines

被引：17

作者：

Asamdi, Manjoorahmed ^{[1
]}

Shaikh, Mohammedumar M. ^{[1
]}

Chauhan, Prakashsingh M. ^{[1
]}

Chikhalia, Kishor H. ^{[2
]}

机构：

[1] Gujarat Univ, Dept Chem, Ahmadabad 380009, Gujarat, India

[2] Veer Narmad South Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India

来源：

TETRAHEDRON | 2018年 / 74卷 / 27期

关键词：

Pd catalyst; 5+2] annulation; C-H activation; Alkyne; Palladacycle; OH BOND ACTIVATION; STEREOSELECTIVE-SYNTHESIS; ANTI-HIV-1; ACTIVITY; EFFICIENT SYNTHESIS; COUPLING REACTION; TIBO DERIVATIVES; FUNCTIONALIZATION; TOSYLHYDRAZONES; CONSTRUCTION; HETEROCYCLES;

D O I：

10.1016/j.tet.2018.05.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and novel method using palladium catalyst for the synthesis of benzo[d][1,2]diazepines by [5 + 2] annulation of N-arylhydrazones with alkynes has been developed. This methodology undergoes through eight membered palladacycle serving as a backbone for the formation of C-C/C-N bond to provide benzodiazepine derivatives in moderate to good yield. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：3719 / 3727

页数：9

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