A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

被引：96
作者：
Saleem, Sumaira [1 ]
Muhammad, Gulzar [1 ,2 ]
Hussain, Muhammad Ajaz [2 ]
Bukhari, Syed Nasir Abbas [3 ]
机构：
[1] GC Univ Lahore, Dept Chem, Lahore 54000, Pakistan
[2] Univ Sargodha, Dept Chem, Sargodha 40100, Pakistan
[3] Jouf Univ, Dept Pharmaceut Chem, Coll Pharm, Aljouf 2014, Sakakah, Saudi Arabia
来源：
PHYTOTHERAPY RESEARCH | 2018年 / 32卷 / 07期
关键词：
Azadirachta indica; azadirachtin; bioactives; medicinal uses; neem; pharmacological attributes; secondary metabolites; SEED KERNEL EXTRACTS; NEEM-BASED INSECTICIDE; UNCRUSHED GREEN LEAVES; IN-VITRO GROWTH; A.-JUSS; LEAF EXTRACT; ANTIBACTERIAL ACTIVITY; MEDICINAL-PLANTS; STEM BARK; SCHISTOCERCA-GREGARIA;
D O I：
10.1002/ptr.6076
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties. A.indica is also rich in various phytochemicals for pharmaceuticals such as alkaloids, steroids, flavonoids, terpenoids, fatty acids, and carbohydrates. The fungicidal potential of the tree is due to the presence of azadirachtin and nimbin. Herein, we have compiled a comprehensive review of phytochemical profile, pharmacological attributes, and therapeutic prospective of this multipurpose tree.
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页码：1241 / 1272
页数：32
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