EVALUATION OF PRIDOPIDINE IN THE TRANSGENIC YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE

被引:0
|
作者
Miralles, Marta Garcia [1 ]
Tan, Liang Juin [1 ]
Lim, Madeline [1 ]
Geva, Michal [2 ]
Hayden, Michael R. [1 ,2 ,3 ,4 ]
Pouladi, Mahmoud A. [1 ,3 ,4 ]
机构
[1] Translat Lab Genet Med, Singapore, Singapore
[2] Teva Pharmaceut, Res & Dev, Netanya, Israel
[3] Univ British Columbia, Child & Family Res Inst, Ctr Mol Med & Therapeut, Vancouver, BC, Canada
[4] Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore
关键词
D O I
10.1136/jnnp-2016-314597.261
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
L6
引用
收藏
页码:A92 / A92
页数:1
相关论文
共 50 条
  • [41] Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
    Van Raamsdonk, Jeremy M.
    Metzler, Martina
    Slow, Elizabeth
    Pearson, Jacqueline
    Schwab, Claudia
    Carroll, Jeffrey
    Graham, Rona K.
    Leavitt, Blair R.
    Hayden, Michael R.
    NEUROBIOLOGY OF DISEASE, 2007, 26 (01) : 189 - 200
  • [42] BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice
    Xie, Yuxiang
    Hayden, Michael R.
    Xu, Baoji
    JOURNAL OF NEUROSCIENCE, 2010, 30 (44): : 14708 - 14718
  • [43] Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease
    Garcia-Miralles, Marta
    Yusof, Nur Amirah Binte Mohammad
    Tan, Jing Ying
    Radulescu, Carola, I
    Sidik, Harwin
    Tan, Liang Juin
    Belinson, Haim
    Zach, Neta
    Hayden, Michael R.
    Pouladi, Mahmoud A.
    MOLECULAR NEUROBIOLOGY, 2019, 56 (06) : 4464 - 4478
  • [44] Time-Course Analysis of Protein and Lipid Oxidation in the Brains of Yac128 Huntington's Disease Transgenic Mice
    Brocardo, Patricia S.
    McGinnis, Eric
    Christie, Brian R.
    Gil-Mohapel, Joana
    REJUVENATION RESEARCH, 2016, 19 (02) : 140 - 148
  • [45] Silencing Mutant Htt by AAV-Mediated Expression of RNAi Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease
    Stanek, Lisa M.
    Shihabuddin, Lamya S.
    Cheng, Seng H.
    MOLECULAR THERAPY, 2013, 21 : S108 - S108
  • [46] p35 HEMIZYGOSITY ACTIVATES Akt BUT DOES NOT IMPROVE MOTOR FUNCTION IN THE YAC128 MOUSE MODEL OF HUNTINGTON'S DISEASE
    Park, Kevin H. J.
    Franciosi, Sonia
    Parrant, Kristina
    Lu, Ge
    Leavitt, Blair R.
    NEUROSCIENCE, 2017, 352 : 79 - 87
  • [47] Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease
    Van Raamsdonk, JM
    Pearson, J
    Rogers, DA
    Bissada, N
    Vogl, AW
    Hayden, MR
    Leavitt, BR
    HUMAN MOLECULAR GENETICS, 2005, 14 (10) : 1379 - 1392
  • [48] Antisense Oligonucleotide-Mediated Correction of Transcriptional Dysregulation is Correlated with Behavioral Benefits in the YAC128 Mouse Model of Huntington's Disease
    Stanek, Lisa M.
    Yang, Wendy
    Angus, Stuart
    Sardi, Pablo S.
    Hayden, Michael R.
    Hung, Gene H.
    Bennett, C. Frank
    Cheng, Seng H.
    Shihabuddin, Lamya S.
    JOURNAL OF HUNTINGTONS DISEASE, 2013, 2 (02) : 217 - 228
  • [49] Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease
    Silva, Ana C.
    Ferreira, Ildete L.
    Hayden, Michael R.
    Ferreiro, Elisabete
    Rego, A. Cristina
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2018, 1864 (01): : 34 - 44
  • [50] Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease
    Graham, Rona K.
    Pouladi, Mahmoud A.
    Joshi, Prasad
    Lu, Ge
    Deng, Yu
    Wu, Nan-Ping
    Figueroa, Bryan E.
    Metzler, Martina
    Andre, Veronique M.
    Slow, Elizabeth J.
    Raymond, Lynn
    Friedlander, Robert
    Levine, Michael S.
    Leavitt, Blair R.
    Hayden, Michael R.
    JOURNAL OF NEUROSCIENCE, 2009, 29 (07): : 2193 - 2204