Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy

被引：63

作者：

Feng, Yanlin ^{[1
,2
]}

Cheng, Yan ^{[1
]}

Chang, Yun ^{[1
]}

Jian, Hui ^{[1
]}

Zheng, Runxiao ^{[1
,2
]}

Wu, Xiaqing ^{[1
,2
]}

Xu, Keqiang ^{[1
,2
]}

Wang, Li ^{[3
]}

Ma, Xiaomin ^{[3
]}

Li, Xi ^{[3
]}

Zhang, Haiyuan ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China

[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China

[3] Changchun Univ Technol, Sch Chem & Life Sci, 2055 Yanan St, Changchun 130012, Jilin, Peoples R China

来源：

BIOMATERIALS | 2019年 / 217卷

基金：

中国国家自然科学基金;

关键词：

Gold nanocage; Erlotinib; Doxorubicin; Chemophototherapy; Combination therapy; DRUG-DELIVERY; NANOPARTICLES; CHEMOTHERAPY; CHEMOPHOTOTHERAPY; PERMEABILITY; NANOCARRIER; RECEPTORS; STABILITY; OXIDE;

D O I：

10.1016/j.biomaterials.2019.119327

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Photochemotherapy is currently an effective anticancer therapy. Recently, it has been reported that cancer cells pretreated with epidermal growth factor receptor (EGFR) inhibitor erlotinib (Erl) can significantly synergize its apoptosis against the DNA damaging agent doxorubicin (Dox). As a result, we designed two gold nanocages (Au NCs) microcontainers covered with different smart polymer shell-PAA (pH responsive) and p (NIPAM-co-AM) (temperature responsive) containing Erl and Dox respectively. The acidic tumor microenvironment and NIR light irradiation can selectively activate the release of Erl and Dox. Time staggered release of Erl and Dox and photothermal therapy enhance the apoptotic signaling pathways, resulting in improved tumor cell killing in both MCF-7 (low EGFR expression) and A431 (very high EGFR expression) tumor cells, but more efficient in the latter. The photochemotherapy strategy controls the order and duration of drug exposure precisely in spatial and temporal, and significantly improves the therapeutic efficacy against high EGFR expressed tumors.

引用

页数：13

共 62 条

[1] Effect of gold alloying on stability of silver nanoparticles and control of silver ion release from vapor-deposited Ag-Au/polytetrafluoroethylene nanocomposites [J].