Lipase/aluminum-catalyzed dynamic kinetic resolution of secondary alcohols

被引：91

作者：

Berkessel, Albrecht ^{[1
]}

Sebastian-Ibarz, M. Luisa ^{[1
]}

Mueller, Thomas N. ^{[1
]}

机构：

[1] Univ Cologne, Inst Organ Chem, D-50939 Cologne, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 39期

关键词：

aluminum; kinetic resolution; lipases; metal catalysis; secondary alcohols;

D O I：

10.1002/anie.200600379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Racemization wanted: The dynamic kinetic resolution of secondary alcohols can be achieved by a simple and readily available catalyst system. Substrate racemization is effected at room temperature by a combination of (racemic) 1,1′-bi-2-naphthol (binol) or 2,2′-biphenol with AIMe3, and a lipase performs enantiospecific acylation (see scheme). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6567 / 6570

页数：4

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