Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

被引：118

作者：

Murgatroyd, C. ^{[1
]}

Quinn, J. P. ^{[2
]}

Sharp, H. M. ^{[3
]}

Pickles, A. ^{[4
]}

Hill, J. ^{[5
]}

机构：

[1] Manchester Metropolitan Univ, Sch Healthcare Sci, Manchester M15 6BH, Lancs, England

[2] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England

[3] Univ Liverpool, Inst Psychol Hlth & Soc, Liverpool L69 3BX, Merseyside, England

[4] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

[5] Univ Reading, Sch Psychol & Cinical Language Sci, Reading RG6 6AL, Berks, England

来源：

TRANSLATIONAL PSYCHIATRY | 2015年 / 5卷

基金：

英国医学研究理事会;

关键词：

DNA METHYLATION; STRESS; EXPOSURE; NR3C1; CORTISOL; EPIGENETICS; PERSISTENT; PREGNANCY; ANXIETY; REGION;

D O I：

10.1038/tp.2014.140

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In animal models, prenatal and postnatal stress is associated with elevated hypothalamic-pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expression. In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.

引用

页码：e560 / e560

页数：5

共 38 条

[1] FETAL ORIGINS OF CORONARY HEART-DISEASE [J].

BARKER, DJP .

BRITISH MEDICAL JOURNAL, 1995, 311 (6998) :171-174

[2] THE CONTRIBUTION OF PRENATAL AND POSTNATAL MATERNAL ANXIETY AND DEPRESSION TO CHILD MALADJUSTMENT [J].

Barker, Edward D. ;

Jaffee, Sara R. ;

Uher, Rudolf ;

Maughan, Barbara .

DEPRESSION AND ANXIETY, 2011, 28 (08) :696-702

[3] Differentiating Early-Onset Persistent Versus Childhood-Limited Conduct Problem Youth [J].

Barker, Edward D. ;

Maughan, Barbara .

AMERICAN JOURNAL OF PSYCHIATRY, 2009, 166 (08) :900-908

[4] Developmental plasticity and human health [J].

Bateson, P ;

Barker, D ;

Clutton-Brock, T ;

Deb, D ;

D'Udine, B ;

Foley, RA ;

Gluckman, P ;

Godfrey, K ;

Kirkwood, T ;

Lahr, MM ;

McNamara, J ;

Metcalfe, NB ;

Monaghan, P ;

Spencer, HG ;

Sultan, SE .

NATURE, 2004, 430 (6998) :419-421

[5] The influence of perinatal complications and environmental adversity on boys' antisocial behavior [J].

Beck, JE ;

Shaw, DS .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2005, 46 (01) :35-46

[6] ROBUST LOCALLY WEIGHTED REGRESSION AND SMOOTHING SCATTERPLOTS [J].

CLEVELAND, WS .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1979, 74 (368) :829-836

[7] The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior [J].

Conradt, Elisabeth ;

Lester, Barry M. ;

Appleton, Allison A. ;

Armstrong, David A. ;

Marsit, Carmen J. .

EPIGENETICS, 2013, 8 (12) :1321-1329

[8] Prediction from low birth weight to female adolescent depression - A test of competing hypotheses [J].

Costello, Elizabeth Jane ;

Worthman, Carol ;

Erkanli, Alaattin ;

Angold, Adrian .

ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (03) :338-344

[9] Validation of the Edinburgh postnatal depression scale (EPDS) in non-postnatal women [J].

Cox, JL ;

Chapman, G ;

Murray, D ;

Jones, P .

JOURNAL OF AFFECTIVE DISORDERS, 1996, 39 (03) :185-189

[10] Prenatal exposure to maternal depression and cortisol influences infant temperament [J].

Davis, Elysia Poggi ;

Glynn, Laura M. ;

Schetter, Christine Dunkel ;

Hobel, Calvin ;

Chicz-Demet, Aleksandra ;

Sandman, Curt A. .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2007, 46 (06) :737-746

← 1 2 3 4 →