Epithelial Plasticity versus EMT in Kidney Fibrosis

被引：61

作者：

Huang, Shizheng ^{[1
]}

Susztak, Katalin ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Genet, Renal Electrolyte & Hypertens Div,Dept Med, Philadelphia, PA 19104 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 01期

关键词：

MESENCHYMAL TRANSITION; RENAL FIBROSIS; FIBROBLASTS; DISEASE;

D O I：

10.1016/j.molmed.2015.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten percent of the population worldwide suffers from chronic kidney disease (CKD), characterized by fibrotic changes in the kidney. Fibrosis is associated with loss of epithelial parenchyma, and accumulation of myofibroblasts, fibrillary collagen, and inflammatory cells. Two recent papers highlight the critical role of Twist and Snail transcription factors in kidney fibrosis.

引用

页码：4 / 6

页数：3

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