Selective Release of Aromatic Heterocycles from Ruthenium Tris(2-pyridylmethyl)amine with Visible Light

被引：30

作者：

Li, Ao ^{[1
]}

White, Jessica K. ^{[2
]}

Arora, Karan ^{[1
]}

Herroon, Mackenzie K. ^{[3
]}

Martin, Philip D. ^{[1
]}

Schlegel, H. Bernhard ^{[1
]}

Podgorski, Izabela ^{[3
,4
]}

Turro, Claudia ^{[2
]}

Kodanko, Jeremy J. ^{[1
,4
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA

[3] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA

[4] Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USA

来源：

INORGANIC CHEMISTRY | 2016年 / 55卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

COMPLEXES; LIGAND; PHOTODISSOCIATION;

D O I：

10.1021/acs.inorgchem.5b02600

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three complexes of the general formula [Ru(TPA)L-2] (PF6)(2) [TPA = tris(((2-pyridylmethyl)amine)], where L = pyridine (1), nicotinamide (2), and imidazole (3), were prepared and characterized spectroscopically. Xray crystallographic data were obtained for 1 and 3. Complexes 1-3 show strong absorption in the visible region and selective release of heterocycles upon irradiation with visible light. Time-dependent density functional theory calculations are consistent with the presence of singlet metal-to-ligand charge-transfer bands in the visible region in 1-3. Caged heterocycles 1-3 are highly stable in solution in the dark, including in cell growth media. Cell viability data show no signs of toxicity of 1-3 against PC-3 cells at concentrations up to 100 mu M under light and dark conditions, consistent with Ru(TPA) acting as a nontoxic and effective photocaging group for aromatic heterocycles.

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收藏

页码：10 / 12

页数：3

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