From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal

被引：264

作者：

Asa, S. L. ^{[1
,2
]}

Casar-Borota, O. ^{[3
]}

Chanson, P. ^{[4
]}

Delgrange, E. ^{[5
]}

Earls, P. ^{[6
]}

Ezzat, S. ^{[7
,8
,9
]}

Grossman, A. ^{[10
]}

Ikeda, H. ^{[11
]}

Inoshita, N. ^{[12
]}

Karavitaki, N. ^{[13
]}

Korbonits, M. ^{[14
]}

Laws, E. R., Jr. ^{[15
]}

Lopes, M. B. ^{[16
,17
]}

Maartens, N. ^{[18
]}

McCutcheon, I. E. ^{[19
]}

Mete, O. ^{[1
,2
]}

Nishioka, H. ^{[20
]}

Raverot, G. ^{[21
]}

Roncaroli, F. ^{[22
]}

Saeger, W. ^{[23
]}

Syro, L. V. ^{[24
]}

Vasiljevic, A. ^{[25
]}

Villa, C. ^{[26
]}

Wierinckx, A. ^{[27
]}

Trouillas, J. ^{[28
]}

机构：

[1] Univ Toronto, Dept Pathol, Toronto, ON, Canada

[2] Univ Toronto, Endocrine Oncol Site Grp, Princess Margaret Canc Ctr, Univ Hlth Network,Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Univ Uppsala Hosp, Dept Pathol, Uppsala, Sweden

[4] Hop Bicetre, Serv Endocrinol & Reprod Dis, Paris, France

[5] Univ Louvain, Dept Med, Mont Sur Meuse, Belgium

[6] St Vincents Hosp, Dept Anat Pathol, Sydney, NSW, Australia

[7] Univ Hlth Network, Princess Margaret Canc Ctr, Dept Med, Toronto, ON, Canada

[8] Univ Hlth Network, Princess Margaret Canc Ctr, Endocrine Oncol Site Grp, Toronto, ON, Canada

[9] Univ Toronto, Toronto, ON, Canada

[10] Univ Oxford, Dept Endocrinol, Oxford, England

[11] Southern Tohoku Gen Hosp, Res Inst Pituitary Dis, Fukushima, Japan

[12] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan

[13] Univ Birmingham, Queen Elizabeth Hosp, Dept Endocrinol, Birmingham, W Midlands, England

[14] Queen Mary Hosp, Barts & London Sch Med, Div Endocrinol, London, England

[15] Brigham & Womens Hosp, Harvard Med Sch, Dept Neurosurg, Boston, MA USA

[16] Univ Virginia, Dept Pathol, Charlottesville, VA USA

[17] Univ Virginia, Dept Neurol Surg, Charlottesville, VA USA

[18] Univ Melbourne, Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Vic, Australia

[19] UT MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA

[20] Toranomon Gen Hosp, Dept Neurosurg, Tokyo, Japan

[21] Univ Lyon, Hosp Civils Lyon, Groupement Hosp EST, Dept Endocrinol, Lyon, France

[22] Imperial Coll, Dept Neuropathol, London, England

[23] Univ Hamburg, Inst Neuropathol, Hamburg, Germany

[24] Hosp Pablo Tobon Uribe, Dept Neurosurg, Medellin, Colombia

[25] Univ Lyon, Hosp Civils Lyon, Groupement Hosp EST, Dept Pathol, Lyon, France

[26] Hop Foch, Dept Pathol, Suresnes, France

[27] Univ Lyon, Canc Res Ctr Lyon, INSERM, U1052, Lyon, France

[28] Univ Lyon, Fac Med Lyon Est, Lyon, France

来源：

关键词：

pituitary tumors; nomenclature; PROGNOSTIC CLINICOPATHOLOGICAL CLASSIFICATION;

D O I：

10.1530/ERC-17-0004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

引用

页码：C5 / C8

页数：4

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