URINE BIOMARKER ASSESSMENT OF INFANT ADHERENCE TO ISONIAZID PROPHYLAXIS

被引：3

作者：

LaCourse, Sylvia M. ^{[1
,2
]}

Leon, Daniel ^{[3
]}

Panpradist, Nuttada ^{[3
]}

Richardson, Barbra A. ^{[2
,4
]}

Maleche-Obimbo, Elizabeth ^{[7
]}

Mecha, Jerphason ^{[8
]}

Matemo, Daniel ^{[8
]}

Escudero, Jaclyn N. ^{[2
]}

Kinuthia, John ^{[8
,9
]}

Lutz, Barry ^{[2
,3
]}

John-Stewart, Grace ^{[1
,2
,5
,6
]}

机构：

[1] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA USA

[2] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[3] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[4] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[6] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[7] Univ Nairobi, Dept Pediat & Child Hlth, Nairobi, Kenya

[8] Kenyatta Natl Hosp, Dept Res & Programs, Nairobi, Kenya

[9] Kenyatta Natl Hosp, Dept Obstet & Gynaecol, Nairobi, Kenya

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2021年 / 40卷 / 01期

基金：

美国国家卫生研究院;

关键词：

infant; tuberculosis; prevention; isoniazid; adherence; urine; PREVENTIVE THERAPY; ARKANSAS METHOD; TUBERCULOSIS; CHILDREN; ADULTS; EXPOSURE;

D O I：

10.1097/INF.0000000000002936

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed: 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.

引用

页码：E43 / E45

页数：3

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