Androgen Receptor Signaling in Bladder Cancer

被引：79

作者：

Li, Peng ^{[1
,2
,3
]}

Chen, Jinbo ^{[4
,5
,6
]}

Miyamoto, Hiroshi ^{[1
,2
,4
,5
,7
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21287 USA

[3] Shandong Univ, Shandong Prov Hosp Affiliated, Minimally Invas Urol Ctr, Jinan 250021, Peoples R China

[4] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA

[5] Univ Rochester, Med Ctr, James P Wilmot Canc Ctr, Rochester, NY 14642 USA

[6] Cent South Univ, Xiangya Hosp, Dept Urol, Changsha 410008, Hunan, Peoples R China

[7] Univ Rochester, Med Ctr, Dept Urol, Rochester, NY 14642 USA

来源：

CANCERS | 2017年 / 9卷 / 02期

关键词：

androgen; androgen receptor; anti-androgen; carcinogenesis; tumor progression; urothelial cancer; LOWER URINARY-TRACT; TRANSITIONAL-CELL-CARCINOMA; STEROID-HORMONE RECEPTORS; DEPRIVATION THERAPY; PROGNOSTIC-SIGNIFICANCE; UROTHELIAL CARCINOMA; ESTROGEN-RECEPTORS; EXPRESSION; PROGRESSION; GROWTH;

D O I：

10.3390/cancers9020020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Emerging preclinical findings have indicated that steroid hormone receptor signaling plays an important role in bladder cancer outgrowth. In particular, androgen-mediated androgen receptor signals have been shown to correlate with the promotion of tumor development and progression, which may clearly explain some sex-specific differences in bladder cancer. This review summarizes and discusses the available data, suggesting the involvement of androgens and/or the androgen receptor pathways in urothelial carcinogenesis as well as tumor growth. While the precise mechanisms of the functions of the androgen receptor in urothelial cells remain far from being fully understood, current evidence may offer chemopreventive or therapeutic options, using androgen deprivation therapy, in patients with bladder cancer.

引用

页数：14

共 97 条

[31] Androgen deprivation therapy prevents bladder cancer recurrence [J].

Izumi, Koji ;

Taguri, Masataka ;

Miyamoto, Hiroshi ;

Hara, Yoshinori ;

Kishida, Takeshi ;

Chiba, Kimio ;

Murai, Tetsuo ;

Hirai, Kotaro ;

Suzuki, Kotaro ;

Fujinami, Kiyoshi ;

Ueki, Teiichiro ;

Udagawa, Koichi ;

Kitami, Kazuo ;

Moriyama, Masatoshi ;

Miyoshi, Yasuhide ;

Tsuchiya, Futoshi ;

Ikeda, Ichiro ;

Kobayashi, Kazuki ;

Sato, Maho ;

Morita, Satoshi ;

Noguchi, Kazumi ;

Uemura, Hiroji .

ONCOTARGET, 2014, 5 (24) :12665-12674

[32] Expression of UDP-glucuronosyltransferase 1A in bladder cancer: Association with prognosis and regulation by estrogen [J].

Izumi, Koji ;

Li, Yi ;

Ishiguro, Hitoshi ;

Zheng, Yichun ;

Yao, Jorge L. ;

Netto, George J. ;

Miyamoto, Hiroshi .

MOLECULAR CARCINOGENESIS, 2014, 53 (04) :314-324

[33] Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: A potential mechanism of androgen-induced bladder carcinogenesis [J].

Izumi, Koji ;

Zheng, Yichun ;

Hsu, Jong-Wei ;

Chang, Chawnshang ;

Miyamoto, Hiroshi .

MOLECULAR CARCINOGENESIS, 2013, 52 (02) :94-102

[34] Epidermal growth factor induces bladder cancer cell proliferation through activation of the androgen receptor [J].

Izumi, Koji ;

Zheng, Yichun ;

Li, Yi ;

Zaengle, Jacqueline ;

Miyamoto, Hiroshi .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 41 (05) :1587-1592

[35]

Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]

[36] Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition [J].

Jing, Yifeng ;

Cui, Di ;

Guo, Wenhuan ;

Jiang, Juntao ;

Jiang, Bo ;

Lu, Youyi ;

Zhao, Wei ;

Wang, Xiaohai ;

Jiang, Qi ;

Han, Bangmin ;

Xia, Shujie .

CANCER LETTERS, 2014, 348 (1-2) :135-145

[37] Androgen receptor inducing bladder cancer progression by promoting an epithelial-mesenchymal transition [J].

Jitao, W. ;

Jinchen, H. ;

Qingzuo, L. ;

Li, C. ;

Lei, S. ;

Jianming, W. ;

Zhenli, G. .

ANDROLOGIA, 2014, 46 (10) :1128-1133

[38] Conditional Expression of the Androgen Receptor Increases Susceptibility of Bladder Cancer in Mice [J].

Johnson, Daniel T. ;

Hooker, Erika ;

Luong, Richard ;

Yu, Eun-Jeong ;

He, Yongfeng ;

Gonzalgo, Mark L. ;

Sun, Zijie .

PLOS ONE, 2016, 11 (02)

[39] Effect of castration on male rabbit lower urinary tract tissue enzymes [J].

Juan, Yung-Shun ;

Onal, Bulent ;

Broadaway, Samuel ;

Cosgrove, Julia ;

Leggett, Robert E. ;

Whitbeck, Catherine ;

De, Elise ;

Sokol, Rebekah ;

Levin, Robert M. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2007, 301 (1-2) :227-233

[40] Enzalutamide inhibits proliferation of gemcitabine-resistant bladder cancer cells with increased androgen receptor expression [J].

Kameyama, Koji ;

Horie, Kengo ;

Mizutani, Kosuke ;

Kato, Taku ;

Fujita, Yasunori ;

Kawakami, Kyojiro ;

Kojima, Toshio ;

Miyazaki, Tatsuhiko ;

Deguchi, Takashi ;

Ito, Masafumi .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 50 (01) :75-84

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