Dynamics of actin filaments in motility assays -: A microscopic model and its numerical simulation

被引：0

作者：

Farkas, Z ^{[1
]}

Derényi, I ^{[1
]}

Vicsek, T ^{[1
]}

机构：

[1] Eotvos Lorand Univ, Dept Biol Phys, H-1518 Budapest, Hungary

来源：

STRUCTURE AND DYNAMICS OF CONFINED POLYMERS | 2002年 / 87卷

关键词：

actin filament; computer simulation; Langevin equation; microscopic model; motility assays; myosin;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigate a microscopic model of in-vitro motility assays in which actin filaments slide over a layer of myosin heads attached to a glass plate. The resulting set of Langevin equations is solved, and the numerical results are compared to those observed in the related experiments. The agreement is very good, suggesting that our model can predict the behavior under modified conditions or determine some of the parameters that cannot be measured directly, by finding the best fit to the experimentally observed quantities.

引用

页码：327 / 332

页数：6

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