Erythema multiforme-like cutaneous lesions in monomorphic epitheliotropic intestinal T-cell lymphoma: a rare case report

被引:12
作者
Aiempanakit, Kumpol [1 ]
Amatawet, Chitiarpa [1 ]
Chiratikarnwong, Kanokphorn [1 ]
Auepemkiate, Sauvarat [2 ]
Kayasut, Kanita [2 ]
Suwiwat, Supaporn [2 ]
Apinantriyo, Benjawan [3 ]
机构
[1] Prince Songkla Univ, Div Dermatol, Dept Internal Med, Fac Med, Hat Yai 90110, Songkhla, Thailand
[2] Prince Songkla Univ, Dept Pathol, Fac Med, Hat Yai, Thailand
[3] Bangkok Hatyai Hosp, Hematol Unit, Songkhla, Thailand
关键词
enteropathy-associated T-cell lymphoma; erythema multiforme-like; monomorphic epitheliotropic intestinal T-cell lymphoma; pagetoid; ENTEROPATHY; CLASSIFICATION;
D O I
10.1111/cup.12864
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), also known as Type II enteropathy-associated T-cell lymphoma (EATL), is an aggressive peripheral T-cell lymphoma. EATL generally presents in adults with gastrointestinal symptoms. Skin involvement is very rare, found only in approximately five percent of patients. The authors report a 67-year-old Asian male who presented with chronic diarrhea and developed erythema multiforme-like cutaneous lesions. A skin biopsy revealed extensive pagetoid spread of atypical lymphocytes in the epidermis. The results of an immunohistochemistry test led to a diagnosis of MEITL. This report points to the need for dermatologists and dermatopathologists to consider a possible diagnosis of MEITL when encountering similar cases.
引用
收藏
页码:183 / 188
页数:6
相关论文
共 23 条
[1]   Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas - A distinct clinicopathological entity with an aggressive clinical behavior [J].
Berti, E ;
Tomasini, D ;
Vermeer, MH ;
Meijer, CJLM ;
Alessi, E ;
Willemze, R .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (02) :483-492
[2]   Type II Enteropathy-Associated T-Cell Lymphoma: A Distinct Aggressive Lymphoma With Frequent γδ T-cell Receptor Expression [J].
Chan, John K. C. ;
Chan, Alexander C. L. ;
Cheuk, Wah ;
Wan, Suk-King ;
Lee, Wai-Ki ;
Lui, Yun-Hoi ;
Chan, Wai-Kong .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2011, 35 (10) :1557-1569
[3]   Peripheral T-cell lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upaEuro [J].
d'Amore, F. ;
Gaulard, P. ;
Truemper, L. ;
Corradini, P. ;
Kim, W. -S. ;
Specht, L. ;
Pedersen, M. Bjerregaard ;
Ladetto, M. .
ANNALS OF ONCOLOGY, 2015, 26 :V108-V115
[4]   Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project [J].
Delabie, Jan ;
Holte, Harald ;
Vose, Julie M. ;
Ullrich, Fred ;
Jaffe, Elaine S. ;
Savage, Kerry J. ;
Connors, Joseph M. ;
Rimsza, Lisa ;
Harris, Nancy L. ;
Mueller-Hermelink, Konrad ;
Ruediger, Thomas ;
Coiffier, Bertrand ;
Gascoyne, Randy D. ;
Berger, Francoise ;
Tobinai, Kensei ;
Au, Wing Y. ;
Liang, Raymond ;
Montserrat, Emili ;
Hochberg, Ephraim P. ;
Pileri, Stefano ;
Federico, Massimo ;
Nathwani, Bharat ;
Armitage, James O. ;
Weisenburger, Dennis D. .
BLOOD, 2011, 118 (01) :148-155
[5]   Enteropathy-associated T-cell lymphoma [J].
Ferreri, Andres J. M. ;
Zinzani, Pier Luigi ;
Govi, Silvia ;
Pileri, Stefano A. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2011, 79 (01) :84-90
[6]  
Jaffe E.S., 2009, American Society of Hematology. Education Program, P523
[7]   Peripheral T-cell and NK-cell lymphomas in the WHO classification: pearls and pitfalls [J].
Jaffe, Elaine S. ;
Nicolae, Alina ;
Pittaluga, Stefania .
MODERN PATHOLOGY, 2013, 26 :S71-S87
[8]   Enteropathy-associated T-cell lymphoma in the US: higher incidence and poorer survival among Asians [J].
Karanam, Pawan K. ;
Al-Hamadani, Mohammed ;
Go, Ronald S. .
BRITISH JOURNAL OF HAEMATOLOGY, 2016, 172 (06) :990-992
[9]   Fatal CD8+ epidermotropic cytotoxic primary cutaneous T-cell lymphoma with multiorgan involvement [J].
Marzano, AV ;
Ghislanzoni, M ;
Gianelli, U ;
Caputo, R ;
Alessi, E ;
Berti, E .
DERMATOLOGY, 2005, 211 (03) :281-285
[10]   JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma [J].
Nairismagi, M-L ;
Tan, J. ;
Lim, J. Q. ;
Nagarajan, S. ;
Ng, C. C. Y. ;
Rajasegaran, V. ;
Huang, D. ;
Lim, W. K. ;
Laurensia, Y. ;
Wijaya, G. C. ;
Li, Z. M. ;
Cutcutache, I. ;
Pang, W. L. ;
Thangaraju, S. ;
Ha, J. ;
Khoo, L. P. ;
Chin, S. T. ;
Dey, S. ;
Poore, G. ;
Tan, L. H. C. ;
Koh, H. K. M. ;
Sabai, K. ;
Rao, H-L ;
Chuah, K. L. ;
Ho, Y-H ;
Ng, S-B ;
Chuang, S-S ;
Zhang, F. ;
Liu, Y-H ;
Pongpruttipan, T. ;
Ko, Y. H. ;
Cheah, P-L ;
Karim, N. ;
Chng, W-J ;
Tang, T. ;
Tao, M. ;
Tay, K. ;
Farid, M. ;
Quek, R. ;
Rozen, S. G. ;
Tan, P. ;
Teh, B. T. ;
Lim, S. T. ;
Tan, S-Y ;
Ong, C. K. .
LEUKEMIA, 2016, 30 (06) :1311-1319